Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53

cappuccion submitted, created time 1 year 8 months (www.nature.com)

Oncostatin M (OSM), a cytokine of the interleukin-6 family, induces growth arrest and differentiation of osteoblastic cells into glial-like/osteocytic cells. Here, we asked whether OSM regulates apoptosis of normal or transformed (osteosarcoma) osteoblasts. We show that OSM sensitizes cells to apoptosis induced by various death inducers such as staurosporine, ultraviolet or tumor necrosis factor-alpha.

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Stat5 activation inhibits prolactin-induced AP-1 activity

addict submitted, created time 1 year 8 months (www.nature.com)

The essential role of prolactin (PRL) in normal mammary gland growth and differentiation has implicated this hormone in the development and progression of breast cancer. Stat5 is the best-characterized mediator of PRL signals. PRL also activates multiple other signals, whose roles in normal and pathologic processes are not well understood. They have shown that PRL stimulates activating protein-1 (AP-1) activity in breast cancer cells, and can cooperate with estradiol in this pathway

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