The Transport Signal on Sec22 for Packaging into COPII-Coated Vesicles Is a Conformational Epitope

badboy submitted, created time 1 year 7 months (www.molecule.org)

"The mechanism of cargo concentration into ER-derived vesicles involves interactions between the COPII vesicular coat complex and cargo transport signals—peptide sequences of 10–15 residues. The SNARE protein Sec22 contains a signal that binds the COPII subcomplex Sec23/24 and specifies its endoplasmic reticulum (ER) exit as an unassembled SNARE. The 200 kDa crystal structure of Sec22 bound to Sec23/24 reveals that the transport signal is a folded epitope rather than a conventional short peptide sequence

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