An analysis of expressed sequence tags of developing castor endosperm using a full-length cDNA library

DanyC submitted, created time 1 year 5 months (www.biomedcentral.com)

"This results suggest that transcriptional regulation of FAD2 and FAH12 genes maybe one of the mechanisms that contribute to a high level of ricinoleate accumulation in castor endosperm. The full-length cDNA library will be used to search for additional genes that affect ricinoleate accumulation in seed oils. Their EST sequences will also be useful to annotate the castor genome, which whole sequence is being generated by shotgun sequencing at the Institute for Genome Research (TIGR)."

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Researchers May Remake Neanderthal DNA

gh0706 submitted, created time 1 year 6 months (www.physorg.com)

According to a research team led by Svante Paabo of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, there is also hope for reconstru-
cting the genome of the mammoth and cave bear, Paabo and his colleagues were able to determine identify some DNA from the original animal and how it broke down over time. They also developed procedures to prevent contamination by the DNA of humans working with the material. Their findings are published in this week's online edition of Proceedings of the National Academy of Sciences.

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Analysis of Rhesus Monkey Genome Uncovers Genetic Differences With Humans, Chimps

medal submitted, created time 1 year 8 months (www.nih.gov)

"An international consortium of researchers has published the genome sequence of the rhesus macaque monkey and aligned it with the chimpanzee and human genomes. Published April 13 in a special section of the journal Science, the analysis reveals that the three primate species share about 93 percent of their DNA, yet have some significant differences among their genes."

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Low copy repeats mediate distal chromosome 22q11.2 deletions: Sequence analysis predicts breakpoint mechanisms

DanyC submitted, created time 1 year 9 months (www.genome.org)

"Genomic disorders contribute significantly to genetic disease and, as detection methods improve, greater numbers are being defined. Paralogous low copy repeats (LCRs) mediate many of the chromosomal rearrangements that underlie these disorders, predisposing chromosomes to recombination errors. Deletions of proximal 22q11.2 comprise the most frequently occurring microdeletion syndrome, DiGeorge/Velocardiofacial syndrome (DGS/VCFS), in which most breakpoints have been localized to a 3 Mb region containing four large LCRs

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