Inhibition of medulloblastoma tumorigenesis by the antiproliferative and pro-differentiative gene PC3

Captnimbus submitted, created time 1 year 6 months (www.fasebj.org)

Medulloblastoma, the most common brain tumor in childhood, appears to originate from cerebellar granule cell precursors (GCPs), located in the external granular layer (EGL) of the cerebellum. The antiproliferative gene PC3 (Tis21/BTG2) promotes cerebellar neurogenesis by inducing GCPs to shift from proliferation to differentiation

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