Signaling to muscle satellite cells

sumsung submitted, created time 9 months 2 weeks (www.nature.com)

Researchers led by Rita Perlingeiro at the University of Texas Southwestern Medical School, differentiated mouse embryonic stem cells into muscle progenitor cells which restored function when infused into mice with a mouse version of Duchenne's muscular dystrophy, a wasting disease.

Submit comment | Blog It | Email It | Keywords: muscular dystrophy skeletal muscle Duchenne's muscular dystrophy Duchenne's progenitor cells stem cells muscles cell signaling

Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation

william submitted, created time 1 year 1 month (www.pnas.org)

Skeletal and smooth muscle can mutually transdifferentiate, but little molecular insight exists as to how each muscle program may be subverted to the other. The myogenic basic helix–loop–helix transcription factors MyoD and myogenin (Myog) direct the development of skeletal muscle and are thought to be dominant over the program of smooth muscle cell (SMC) differentiation.

Submit comment | Blog It | Email It | Keywords: myocardin skeletal muscle smooth muscle helix–loop–helix MyoD Myog

The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome

sumsung submitted, created time 1 year 4 months (www.pnas.org)

We examined the hypothesis that insulin resistance in skeletal muscle promotes the development of atherogenic dyslipidemia, associated with the metabolic syndrome, by altering the distribution pattern of postprandial energy storage.

Submit comment | Blog It | Email It | Keywords: skeletal muscle metabolic insulin

Exercise reverses aging in human skeletal muscle

alpha submitted, created time 1 year 6 months (www.biologynews.net)

"Not only does exercise make most people feel better and perform physical tasks better, it now appears that exercise – specifically, resistance training -- actually rejuvenates muscle tissue in healthy senior citizens."

Submit comment | Blog It | Email It | Keywords: skeletal muscle Exercise muscle restoration

A role for cell sex in stem cell–mediated skeletal muscle regeneration: female cells have higher muscle regeneration efficiency

amanda submitted, created time 1 year 7 months (www.jcb.org)

"We have shown that muscle-derived stem cells (MDSCs) transplanted into dystrophic (mdx) mice efficiently regenerate skeletal muscle. However, MDSC populations exhibit heterogeneity in marker profiles and variability in regeneration abilities. "

Submit comment | Blog It | Email It | Keywords: muscle-derived stem cells dystrophic skeletal muscle cell sex skeletal muscle

The sturdier sex? -- Study by Pittsburgh scientists finds female stem cells work better

amanda submitted, created time 1 year 7 months (www.biologynews.net)

"Female stem cells derived from muscle have a greater ability to regenerate skeletal muscle tissue than male cells, according to a study at Children’s Hospital of Pittsburgh of UPMC."

Submit comment | Blog It | Email It | Keywords: stem cell skeletal muscle Cell Biology

Plectin 1f scaffolding at the sarcolemma of dystrophic (mdx) muscle fibers through multiple interactions with ß-dystroglycan

julie submitted, created time 1 year 7 months (www.jcb.org)

"In skeletal muscle, the cytolinker plectin is prominently expressed at Z-disks and the sarcolemma. Alternative splicing of plectin transcripts gives rise to more than eight protein isoforms differing only in small N-terminal sequences (5–180 residues), four of which (plectins 1, 1b, 1d, and 1f) are found at substantial levels in muscle tissue

Submit comment | Blog It | Email It | Keywords: skeletal muscle sarcolemma muscle tissue

Absence of neck can be bad for health

Darkfrog submitted, created time 1 year 8 months (www.nytimes.com)

No, I'm not talking about the French Revolution or tragic eyelash curler accident. People who work out so much that their necks disappear into a glob of muscle may suffer serious circulatory consequences.

Submit comment | Blog It | Email It | Keywords: Skeletal muscle human health muscle circulation bloot clots embolisms

Salamander trumps toad as Mr Universe

Vampire submitted, created time 1 year 9 months (www.newscientist.com)

Hop away toads, you've lost your title as the world's strongest animal. That honour now passes to the giant palm salamander Bolitoglossa dofleini, whose tongue explodes outward with more instantaneous power than any other known vertebrate muscle. At 18,000 watts of power per kilogram of muscle, the salamander, from the forest floors of Central America, is nearly twice as strong as the previous champ, the Colorado river toad Bufo alvarius

1 comment | Blog It | Email It | Keywords: animal tests Toad muscle Skeletal muscle energy landscape South Africa

GNALING PATHWAYS IN SKELETAL MUSCLE REMODELING

BIOBOSS submitted, created time 1 year 9 months (arjournals.annualreviews.org)

Skeletal muscle is comprised of heterogeneous muscle fibers that differ in their physiological and metabolic parameters. In response to environmental demands, skeletal muscle remodels by activating signaling pathways to reprogram gene expression to sustain muscle performance.

Studies have been performed using exercise, electrical stimulation, transgenic animal models, disease states, and microgravity to show genetic alterations and transitions of muscle fibers in response to functional demands

Submit comment | Blog It | Email It | Keywords: Skeletal muscle signaling pathways muscular diseases