Chronic exposure to 12-O-tetradecanoylphorbol-13-acetate represses sod2 induction in vivo: The negative role of p50

jiangyun submitted, created time 1 year 4 months (carcin.oxfordjournals.org)

We generated transgenic mice expressing human MnSOD promoter- and enhancer-driven luciferase reporter gene and used a non-invasive imaging system to investigate the effects of TPA on MnSOD expression in vivo. Our data indicate that TPA initially activates MnSOD expression, but this positive effect declines after repeated applications.

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Analysis of overrepresented motifs in human core promoters reveals dual regulatory roles of YY1

captainclaw submitted, created time 1 year 6 months (www.genome.org)

"Researchers has verified that the YY1 motif is bound by YY1 in vitro. They then performed detailed analysis on YY1 chromatin immunoprecipitation data with a whole-genome human promoter microarray (ChIP-chip) and revealed that the thus identified promoters in HeLa cells were highly enriched with the YY1 motif

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The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection

bioman submitted, created time 1 year 6 months (www.pnas.org)

the mechanisms involved in HCF-1-dependent transcriptional stimulation were undefined. By using a minimal HCF-1-dependent promoter and a model activator, the varicella zoster IE62 protein, it was determined that HCF-1 was not required for the assembly of the RNAPII basal complex, which depended solely on IE62 in conjunction with the cellular factor Sp1. These studies also contribute to the model whereby the induced nuclear transport of HCF-1 in sensory neurons may be critical to the reactivation of latent herpesviruses by promoting the activation of chromatin modifications.

Submit comment | Blog It | Email It | Keywords: chromatin histone methyltransferase chromatin modifications Sp1 transcription