Articles with the keyword: 
Stem Cells with Potential to Regenerate Injured Liver Tissue Identified
sea-maid submitted, created time 1 day 15 hours (www.sciencedaily.com)
A novel protein marker has been found that identifies rare adult liver stem cells, whose ability to regenerate injured liver tissue has the potential for cell-replacement therapy. For the first time, researchers at the University of Pennsylvania School of Medicine led by Linda Greenbaum, MD, Assistant Professor of Medicine in the Division of Gastroenterology, have demonstrated that cells expressing the marker can differentiate into both liver cells and cells that line the bile duct.
This discovery could have serious implication for transplants and regenerative medicine 
Umbilical Cord Blood May Help Build New Heart Valves
sea-maid submitted, created time 6 days 16 hours (www.sciencedaily.com)
Children with heart defects may someday receive perfectly-matched new heart valves built using stem cells from their umbilical cord blood, according to research presented at the American Heart Association’s Scientific Sessions 2008.
Genzyme and Osiris partner on stem-cell program
piggy submitted, created time 1 week 6 days (www.boston.com)
Genzyme Corp. and Osiris Therapeutics Inc. said today they will partner to develop and commercialize adult stem cell products with the potential to treat a variety of diseases.
In a press release describing the agreement, Genzyme of Cambridge said it will make a $130 million up-front payment to Maryland-based Osiris, with $75 million paid initially and $55 million to be paid on July 1, 2009. In addition, Osiris also has the potential to receive a total of up to $1.25 billion in milestone payments from Genzyme
Stem cells: A new pathway for stem cell aging and renewal
sea-maid submitted, created time 2 weeks 17 hours (www.nature.com)
Stem cells have the potential for self-renewal and are therefore able to persist throughout life in a diverse range of tissues. However, their self-renewing capacity declines with age. What mechanisms are responsible for the differences between young and aging stem cells? The discovery of a novel pathway involving high-mobility group A2 (HMGA2), INK4A and ARF has recently provided exciting new insights.
Stem-cell law goes to the polls
sea-maid submitted, created time 2 weeks 5 days (www.nature.com)
The 4 November election will settle more than who sits in the White House. The U.S. state of Michigan presently has a law forbidding active research on living human embryos. If a Michigan woman has gone through infertility treatments and wants to donate leftover embryos to the research facilities at the Michigan Center for Human Embryonic Stem Cell Research in Ann Arbor, then she must either throw the embryos away or send them to another state
Cancer stem cells in solid tumors: accumulating evidence and unresolved questions
sea-maid submitted, created time 4 weeks 2 days (www.nature.com)
Solid tumors are an enormous cancer burden and a major therapeutic challenge. The cancer stem cell (CSC) hypothesis provides an attractive cellular mechanism to account for the therapeutic refractoriness and dormant behavior exhibited by many of these tumors. There is increasing evidence that diverse solid tumors are hierarchically organized and sustained by a distinct subpopulation of CSCs. Direct evidence for the CSC hypothesis has recently emerged from mouse models of epithelial tumorigenesis, although alternative models of heterogeneity also seem to apply
Can Mesenchymal Stem Cells Induce Tolerance to Cotransplanted Human Embryonic Stem Cells?
jerry submitted, created time 4 weeks 2 days (www.nature.com)
Mesenchymal stem cells (MSCs) are reported to be immune privileged. We assessed whether their transplantation (Tx) could create a suppressive microenvironment mitigating rejection of coinjected human embryonic stem cells (hESCs)...
sea-maid submitted, created time 1 month 19 hours (www.sciencedirect.com)
Stem cells persist throughout life in diverse tissues by undergoing self-renewing divisions. Self-renewal capacity declines with age, partly because of increasing expression of the tumor suppressor p16Ink4a. We discovered that the Hmga2 transcriptional regulator is highly expressed in fetal neural stem cells but that expression declines with age. This decrease is partly caused by the increasing expression of let-7b microRNA, which is known to target HMGA2
Centrosome misorientation reduces stem cell division during aging
sea-maid submitted, created time 1 month 2 days (www.nature.com)
Asymmetric division of adult stem cells generates one self-renewing stem cell and one differentiating cell, thereby maintaining tissue homeostasis. A decline in stem cell function has been proposed to contribute to tissue aging, although the underlying mechanism is poorly understood. Here we show that changes in the stem cell orientation with respect to the niche during aging contribute to the decline in spermatogenesis in the male germ line of Drosophila. Throughout the cell cycle, centrosomes in germline stem cells (GSCs) are oriented within their niche and this ensures asymmetric division
Generation of pluripotent stem cells from adult human testis
sea-maid submitted, created time 1 month 3 days (www.nature.com)
This is a writeup in Nature of the recent discovery that human and mouse spermatogonial cells can be rendered into pluripotent cell lines with similarities to embryonic stem cells.
"Here we report the successful establishment of human adult germline stem cells derived from spermatogonial cells of adult human testis. Cellular and molecular characterization of these cells revealed many similarities to human embryonic stem cells, and the germline stem cells produced teratomas after transplantation into immunodeficient mice
Testicles could provide "ethical" stem cells
sea-maid submitted, created time 1 month 4 days (www.newscientist.com)
This article provides more information about last week's announcement that researchers have found a form of adult stem cells that appear to be as versatile as embryonic cells ...in men's testicles.
A team out of the University of Tubingen in Germany managed to convert spermatagonial cells into skin, gut structures, cartilage, bone, muscle, and neurons, quite an accomplishment. Some of their colleagues are enthusiastic. Robert Lanza of Advanced Cell Technology in Massachusetts (U.S
MAPC adult stem cells shown to be a hoax ...or at least an error
sea-maid submitted, created time 1 month 5 days (www.newscientist.com)
This is a simple and concise writeup of the recent scandal involving stem cell research team led by Catherine Verfaille of the University of Minnesota that is accused of falsifying data. As it turns out, some of the inconsistencies in the paper in question were only errors, but it has been confirmed that there was also misrepresentation involved. For example, two of the images accompanying a paper that the team published in the journal Blood, meant to represent the results of different experiments, were actually the same image, flipped and altered
Fat-regenerating "stem cells" found in mice
sea-maid submitted, created time 1 month 6 days (esciencenews.com)
Researchers have identified stem cells with the capacity to build fat, according to a report in the October 17th issue of the journal Cell, a Cell Press publication. Although they have yet to show that the cells can renew themselves, they have convirmed that they can renew fat tissue when transplanted into other animals.
Stem cells from testicles offer an alternative to embryos
jerry submitted, created time 1 month 1 week (ap.google.com)
Cells taken from men's testicles seem as versatile as the stem cells derived from embryos, researchers reported Wednesday in what may be yet another new approach in a burgeoning scientific field. The downside? Because of their source, these cells could only be used for regenerative medicine in male patients, not in female ones.
The study involved twenty-two samples from men aged seventeen to eighty-one. All of them men were undergoing treatments for other reasons
Regenerative medicine may have just found a shortcut
sea-maid submitted, created time 1 month 1 week (www.nature.com)
Moving from one differentiated cell type from another may not always require a stopover in an undifferentiated state. This paper shows an alternative route to a differentiated state, which may have serious applications in regenerative medicine and provide real-world applications for human embryonic stem cells.
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