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12

'Scrawny' gene keeps stem cells healthy

piggy submitted, created time 20 hours 40 minutes (www.eurekalert.org)

Stem cells are the body's primal cells, retaining the youthful ability to develop into more specialized types of cells over many cycles of cell division. How do they do it? Scientists at the Carnegie Institution have identified a gene, named scrawny, that appears to be a key factor in keeping a variety of stem cells in their undifferentiated state. Understanding how stem cells maintain their potency has implications both for our knowledge of basic biology and also for medical applications. The results will be published in the January 9, 2009 print edition of Science

7

Hope of insulin cell transplant

sea-maid submitted, created time 1 day 10 hours (news.bbc.co.uk)

Scientists working towards pancreatic cell transplants as a cure for diabetes have taken the first step to getting around the problem of immune rejection.

12

Scientists can now differentiate between healthy cells and cancer cells

piggy submitted, created time 1 day 20 hours (www.eurekalert.org)

One of the current handicaps of cancer treatments is the difficulty of aiming these treatments at destroying malignant cells without killing healthy cells in the process. But a new study by McMaster University researchers has provided insight into how scientists might develop therapies and drugs that more carefully target cancer, while sparing normal healthy cells
Mick Bhatia, scientific director of the McMaster Stem Cell and Cancer Research Institute in the Michael G

12

Fusing Embryonic Stem Cells with Adult Cells Using Highly Efficient New Fusing System

piggy submitted, created time 2 days 21 hours (www.sciencedaily.com)

MIT engineers have developed a new, highly efficient way to pair up cells so they can be fused together into a hybrid cell.

The new technique should make it much easier for scientists to study what happens when two cells are combined. For example, fusing an adult cell and an embryonic stem cell allows researchers to study the genetic reprogramming that occurs in such hybrids

12

Brain Birth Defects Successfully Reversed Through Stem Cell Therapy

piggy submitted, created time 1 week 1 day (www.sciencedaily.com)

Scientists at the Hebrew University of Jerusalem have succeeded in reversing brain birth defects in animal models, using stem cells to replace defective brain cells.

The work of Prof. Joseph Yanai and his associates at the Hebrew University-Hadassah Medical School was presented at the Tel Aviv Stem Cells Conference last spring and is expected to be presented and published nest year at the seventh annual meeting of the International Society for Stem Cell Research in Barcelona, Spain.

Involved in the project with Prof. Yanai are Prof

8

Recipe for capturing authentic embryonic stem cells may apply to any mammal, study suggests

piggy submitted, created time 1 week 5 days (www.eurekalert.org)

Researchers have what they think may be a basic recipe for capturing and maintaining indefinitely the most fundamental of embryonic stem cells from essentially any mammal, including cows, pigs and even humans. Two new studies reported in the December 26th issue of the journal Cell, a Cell Press publication, show that a cocktail first demonstrated to work in mice earlier this year, which includes inhibitory chemicals, also can be used to successfully isolate embryonic stem cells from rats.

Authentic rat embryonic stem cells had never before been established

10

New embryonic stem cells ratted out

sea-maid submitted, created time 1 week 6 days (www.sciencenews.org)

Scientists have finally succeeded in deriving embryonic stem cells from rats, providing the research community with a new tool for modeling human disease. The method used may prove to be a general recipe to create stem cells from many different animals, the researchers say. The findings appear in two companion papers in the Dec. 26 Cell.

13

Vatican toughens stance on embryo research

sea-maid submitted, created time 3 weeks 5 days (www.nature.com)

The Roman Catholic Church has reaffirmed its opposition to embryonic stem cell research in a document that updates its twenty-year-old position on biomedical research and reproductive medicine.

The most significant change is that the Church rejects the idea that scientists who work with tissues derived from stem cells or fetuses are blameless so long as they had no part in the creation of the cell line or tissue sample

10

Novel Human Stem Cell-based Model of Amyotrophic Lateral Sclerosis Opens Doors for Rapid Drug Screening

piggy submitted, created time 1 month 2 days (www.sciencedaily.com)

Long thought of as mere bystanders, astrocytes are crucial for the survival and well-being of motor neurons, which control voluntary muscle movements. In fact, defective astrocytes can lay waste to motor neurons and are the main suspects in the muscle-wasting disease amyotrophic lateral sclerosis (ALS), commonly known as Lou Gherig's disease.

To get to the root of this complicated relationship, researchers from the Salk Institute for Biological Studies for the very first time established a human embryonic stem cell (hESC)-based system for modeling ALS

13

Stem cell research community warns against fraudulent clinics

Darkfrog submitted, created time 1 month 3 days (www.nature.com)

Most scientists will tell you that stem cells show enormous potential and that we could see treatments for anything from diabetes to spinal cord injuries entering clinical trials any day now ...but let them know that the clinic down the street is offering "stem cell treatments" right as we speak, and the reaction gets significantly less optimistic.

The International Society for Stem Cell Research--the same organization that came out against stem cell tourism last year--has warned against clinics offering fraudulent, dangerous and unproven treatments

11

Blood tests may show inherited diseases in fetuses

sea-maid submitted, created time 1 month 1 week (www.reuters.com)

Doctors may soon be able to diagnose inherited diseases such as cystic fibrosis, thalassaemia and sickle cell anemia in fetuses by simply testing a blood sample taken from the mother.

10

Pure Insulin-Producing Cells Produced in Mice

piggy submitted, created time 1 month 2 weeks (www.sciencedaily.com)

Singapore researchers have developed an unlimited number of pure insulin-producing cells from mouse embryonic stem cells (ESCs).

These pure insulin-producing cells, which according to electron microscopy studies, have the same sub-cellular structures as the insulin-producing cells naturally found in the pancreas, were highly effective in treating diabetes in the mouse model.

The transplants of pure insulin-producing cells reduced the blood glucose levels of diabetic mice with high blood glucose levels

12

Stem Cells Spawn First Drug-Free Windpipe Transplant

sea-maid submitted, created time 1 month 2 weeks (www.bloomberg.com)

Doctors operating on a 30-year-old Colombian woman restored her ability to breathe freely with the world's first transplanted windpipe specially treated to prevent organ rejection.

The airway connecting Claudia Castillo Sanchez's left lung to her windpipe collapsed after a persistent tuberculosis infection, leaving her short of breath and unable to perform routine daily activities. Efforts to prop it open failed, leaving Spanish doctors two options: remove the lung or replace the airway using an experimental technique tried only in animals

10

Tissue engineering triumph: Doctors transplant a trachea made from the patient's own stem cells

Darkfrog submitted, created time 1 month 2 weeks (www.lancet.com)

The medical journal Lancet has just announced that doctors have performed the first successful trachea transplant using a trachea crafted from the patient's own stem cells. The New York Times is hailing this as a revolutionary step in regenerative medicine. The surgery took place in Barcelona this past June. Researchers from universities in Spain, Britain and Italy collaborated on the preparation. The patient's original trachea--actually one of her bronchi--had been damaged by severe tuberculosis.

Prof

12

Newborn Neurons in Adult Brain Can Settle in the Wrong Neighborhood

piggy submitted, created time 1 month 2 weeks (www.sciencedaily.com)

In a study that could have significant consequences for neural tissue transplantation strategies, researchers at the Salk Institute for Biological Studies report that inactivating a specific gene in adult neural stem cells makes nerve cells emerging from those precursors form connections in the wrong part of the adult brain.

Researchers, led by Fred H. Gage, Ph.D

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