Expression of hereditary hemochromatosis C282Y HFE protein in HEK293 cells activates specific endoplasmic reticulum stress responses

DanyC submitted, created time 1 year 5 months (www.biomedcentral.com)

"This novel observations suggest that both the ER overload response (EOR) and the unfolded protein response (UPR) are activated by mutant C282Y HFE protein."

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Faster rates of post-puberty kidney deterioration in males is correlated with elevated oxidative stress in males vs females at early puberty

annatto submitted, created time 1 year 5 months (www.biomedcentral.com)

"This data suggest that early puberty, with gender-related elevation in oxidative stress in males, is a key compromising factor on kidneys in males."

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Scientists banish pot bellies without surgery

angelfish submitted, created time 1 year 6 months (www.abc.net.au)

The researchers describe a mechanism they found by which stress activates weight gain in mice.

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Blocking Stress Protein Decreases Alzheimer's Peptide In Mice

diggman submitted, created time 1 year 6 months (www.medicalnewstoday.com)

Scientists revealed in November 2006 that stress increases production in mice of a brain peptide critical to Alzheimer's disease. Now the same group has shown that blocking a different brain peptide slows the stress-induced increase, opening a new door to treatment. Researchers from Washington University School of Medicine in St. Louis report the results online this week in the Proceedings of the National Academy of Sciences.

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