Single-molecule level analysis of the subunit composition of the T cell receptor on live T cells

scott submitted, created time 1 year 3 weeks (www.pnas.org)

The T cell receptor (TCR) expressed on most T cells is a protein complex consisting of TCRαβ heterodimers that bind antigen and cluster of differentiation (CD) 3εδ,εγ,and ζζ dimers that initiate signaling.

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Immunobiological diversity in infant acute lymphoblastic leukemia is related to the occurrence and type of MLL gene rearrangement

amanda submitted, created time 1 year 7 months (www.nature.com)

"The high frequency of immature and oligoclonal Ig/TCR rearrangements is probably caused by early (prenatal) oncogenic transformation in immature B-lineage progenitor cells with germline Ig/TCR genes combined with a short latency period."

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