Articles with the keyword: 
Key Gene May Be Crucial to Production of Thymus and Disease-Fighting T-cells
sea-maid submitted, created time 1 week 6 days (gopast.net)
This research provides the first evidence that a key gene may be crucial to maintaining the production of the thymus and its disease-fighting T-cells after an animal’s birth. 
Zinc-finger proteins turn T-cells HIV-resistant
Darkfrog submitted, created time 4 months 2 weeks (www.nature.com)
ZInc-finger proteins occur naturally in human cells and regulate gene activity. Researchers out of California's Sangamo Biosciences have figured out how to use these proteins to disrupt and disable specific genes. The kicker? When the gene in question is CCR5, human T-cells suddenly become resistant to infection with HIV.
At this point, any practical treatment would involve removing (or growing) the patient's own T-cells, treating them with zinc finger proteins, and then re0injecting the patient. Cumbersome, but possible
Licensed to Kill? -----Islet Autoreactive CD8 T-cells in Type 1 Diabetes
jerry submitted, created time 6 months 1 week (diabetes.diabetesjournals.org)
There are something tell us about the notion that type 1 diabetes is a T-cell–mediated autoimmune disease. It is therefore logical for investigators to direct research efforts toward studies of T-cells. And CD8-positive cytotoxic T-cells have been implicated in the disease process.
Cytokines as Therapeutic Targets: Advances and Limitations
jerry submitted, created time 6 months 1 week (www.immunity.com)
Biological therapies targeting cytokines, T cells, or B cells have improved outcomes of inflammatory diseases. However, many issues remain open: What is the best target? How well can response be predicted? How can cure be achieved?
This article will answer these questions.
CD4+ T cell memory determinant
jerry submitted, created time 6 months 1 week (www.immunity.com)
The requirements for memory CD4+ T cell formation after an acute infection are not well defined.
The researchers find that T cell receptor avidity for antigen is likely to play a key role.
Immune System Reactivated in Adults with HIV: Thymus Producing New T-cells
jane2007 submitted, created time 9 months 1 day (www.sciencedaily.com)
It has been long assumed that the thymus, which loses function because of HIV disease, cannot be reactivated in humans, but new research shows that the thymus can be stimulated to produce more T-cells.
Homotypic Interactions Mediated by Slamf1 and Slamf6 Receptors Control NKT Cell Lineage Development
salut8 submitted, created time 11 months 2 weeks (www.immunity.com)
“Commitment to the T and natural killer T (NKT) cell lineages is determined during αβ T cell receptor (TCR)-mediated interactions of common precursors with ligand-expressing cells in the thymus. Whereas mainstream thymocyte precursors recognize major histocompatibility complex (MHC) ligands expressed by stromal cells, NKT cell precursors interact with CD1d ligands expressed by cortical thymocytes. Here, Klaus et al
Immunology submitted, created time 11 months 2 weeks (www.ncbi.nlm.nih.gov)
Lymphodepletion with total body irradiation (TBI) increases the efficacy of adoptively transferred tumor-specific CD8(+) T cells by depleting inhibitory lymphocytes and increasing homeostatic cytokine levels. We found that TBI augmented the function of adoptively transferred CD8(+) T cells in mice genetically deficient in all lymphocytes, indicating the existence of another TBI mechanism of action. Additional investigation revealed commensal gut microflora in the mesenteric lymph nodes and elevated LPS levels in the sera of irradiated mice
Immunology submitted, created time 11 months 2 weeks (www.ncbi.nlm.nih.gov)
CD25CD4 regulatory T cells (Treg) regulate peripheral self-tolerance and possess the ability to suppress antitumor responses, which may explain the poor clinical response of cancer patients undergoing active immunization protocols, and provides the rationale for neutralizing Treg cells in vivo to strengthen local antitumor immune responses. Because interleukin-2 (IL-2) mediates tumor regression in about 15% of treated patients but simultaneously increases Treg cells, we hypothesized that transient elimination of Treg cells will enhance the clinical effectiveness of IL-2 therapy
Immunology submitted, created time 11 months 3 weeks (www.ncbi.nlm.nih.gov)
BACKGROUND: The human 5T4 (h5T4) oncofoetal antigen is expressed by a wide variety of human carcinomas including colorectal, ovarian, gastric and renal, but rarely on normal tissues. Its restricted expression on tumour tissues as well as its association with tumour progression and bad prognosis has driven the development of a MVA-based vaccine (TroVax) which has been tested in several early phase clinical trials and these studies have led to the start of a phase III trial in renal cell carcinoma patients
Single-molecule level analysis of the subunit composition of the T cell receptor on live T cells
scott submitted, created time 1 year 3 weeks (www.pnas.org)
The T cell receptor (TCR) expressed on most T cells is a protein complex consisting of TCRαβ heterodimers that bind antigen and cluster of differentiation (CD) 3εδ,εγ,and ζζ dimers that initiate signaling.
Naive B-cells generate regulatory T-cells in the presence of a mature immunological synapse
collapsar submitted, created time 1 year 7 months (bloodjournal.hematologylibrary.org)
Naive B-cells are ineffective antigen-presenting cells and considered unable to activate naive T-cells. However, antigen-specific contact of these cells leads to stable cell pairs that remain associated over hours in vivo. The physiological role of such pairs is not evaluated. We show here that antigen-specific conjugates between naive B-cells and naive T-cells display a mature immunological synapse in the contact zone which is absent in T-cell-dendritic cell (DC) pairs. B-cells induce substantial proliferation but contrary to DC no loss of L-Selectin in T-cells
CD8+ T-Cell Responses Identify ß-Cell Autoimmunity in Human Type 1 Diabetes
julie submitted, created time 1 year 8 months (diabetes.diabetesjournals.org)
Despite the understanding that type 1 diabetes pathogenesis is mediated by T-cells, detection of these rare lymphocytes remains largely elusive. Suitable T-cell assays are highly needed, since they could offer preclinical diagnoses and immune surrogate end points for clinical trials.
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