TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis

kavin submitted, created time 6 months 3 weeks (www.cell.com)

It is known that immune homeostasis is essential for the normal functioning of the immune system, and its breakdown leads to fatal inflammatory diseases. In this paper, the authors found that TIPE2 is an essential negative regulator of TLR and TCR function, and its selective expression in the immune system prevents hyperresponsiveness and maintains immune homeostasis.

3 comments | Blog It | Email It | Keywords: TLR TCR homeostasis negative feedback TIPE2 Immune Function Immune System Enzyme mammalian immune system immune system innate immune system TIPE2 Immune Homeostasis

Homotypic Interactions Mediated by Slamf1 and Slamf6 Receptors Control NKT Cell Lineage Development

salut8 submitted, created time 11 months 2 weeks (www.immunity.com)

“Commitment to the T and natural killer T (NKT) cell lineages is determined during αβ T cell receptor (TCR)-mediated interactions of common precursors with ligand-expressing cells in the thymus. Whereas mainstream thymocyte precursors recognize major histocompatibility complex (MHC) ligands expressed by stromal cells, NKT cell precursors interact with CD1d ligands expressed by cortical thymocytes. Here, Klaus et al

1 comment | Blog It | Email It | Keywords: MHC Slamf1 Slamf6 T-cells TCR NKT cell