TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis

kavin submitted, created time 6 months 3 weeks (www.cell.com)

It is known that immune homeostasis is essential for the normal functioning of the immune system, and its breakdown leads to fatal inflammatory diseases. In this paper, the authors found that TIPE2 is an essential negative regulator of TLR and TCR function, and its selective expression in the immune system prevents hyperresponsiveness and maintains immune homeostasis.

3 comments | Blog It | Email It | Keywords: TLR TCR homeostasis negative feedback TIPE2 Immune Function Immune System Enzyme mammalian immune system immune system innate immune system TIPE2 Immune Homeostasis