Human C-reactive protein slows atherosclerosis development in a mouse model with human-like hypercholesterolemia

jiangyun submitted, created time 1 year 4 months (www.pnas.org)

Increased baseline values of the acute-phase reactant C-reactive protein (CRP) are significantly associated with future cardiovascular disease, and some in vitro studies have claimed that human CRP (hCRP) has proatherogenic effects. in vivo studies in apolipoprotein E-deficient mouse models, however, have given conflicting results. We bred atherosclerosis-prone mice (Apob100/100Ldlr–/–), which have human-like hypercholesterolemia, with hCRP transgenic mice (hCRP+/0) and studied lesion development at 15, 30, 40, and 50 weeks of age

Submit comment | Blog It | Email It | Keywords: acute-phase protein apolipoprotein B100 coronary artery disease low-density lipoprotein plaques