Articles with the keyword: 
Gene Scan of Alzheimer's Families Identifies Four New Suspect Genes
sea-maid submitted, created time 2 weeks 6 days (thepasskey.info)
The first family-based genome-wide association study in Alzheimer's disease has identified the sites of four novel genes that may significantly influence risk for the most common late-onset form of the devastating neurological disorder. In their report in the November 7 American Journal of Human Genetics, a team led by researchers from the MassGeneral Institute for Neurodegenerative Disease (MGH-MIND) describes how newly available technology is improving understanding of genetic mechanisms underlying the disease. 
New Facility for Alzheimer's Research
jerry submitted, created time 1 month 3 days (www.whsv.com)
A pair of events in West Virginia are meant to raise awareness about Alzheimer's disease. Officials at the Blanchette Rockefeller Neurosciences Institute in Morgantown dedicated their new center Friday.
New Clue to the Cause of Alzheimer's
jerry submitted, created time 4 months 4 weeks (www.time.com)
The brains of people with the memory-robbing form of dementia are cluttered with a plaque made up of beta-amyloid, a sticky protein...
Alzheimer's Risk Factor Also Aids HIV
sea-maid submitted, created time 4 months 4 weeks (www.sciencemag.org)
The defective lipid carrier apolipoprotein E4 (apoE4) has accumulated a nasty record. Not only are people who have the gene for apoE4 famously predisposed to Alzheimer's disease, but the same risk factor can also worsen several nervous system disorders and promote cardiovascular disease. A study out this week suggests that apoE4 also hastens the death of people infected with HIV, possibly by allowing the virus easy entry into cells.
Analyst awaits data on Wyeth-Elan Alzheimer's drug
kavin submitted, created time 5 months 4 days (money.cnn.com)
By the end of the month, a Cowen and Co. analyst says, Wyeth and Elan Corp. PLC will report clinical trial data for a new kind of Alzheimer's disease treatment _ one that could slow the progress of the disease rather than fighting its symptoms.
Analyst Ian Sanderson calls the test results for bapineuzumab "one of the most anticipated phase II trials in pharmaceutical industry history." He expects Elan and Wyeth to report their findings by the end of June.
The Alzheimer's treatment market is led by four drugs: Pfizer Inc.'s Aricept, Forest Laboratories Inc
Gene silencing made practical: siRNA used to treat neurogenerative disorders in the lab
Darkfrog submitted, created time 5 months 2 weeks (www.jbc.org)
This abstract is about as easy to read as sixteenth-century tax law, but here's the gist: Human neurogenerative disorders, like Huntington's, Parkinson's, Alzheimer's and amyotrophic lateral sclerosis (Lou Gherig's disease) are all caused or exacerbated by the expression of mutant genes. If we switch off the genes--or at least keep them from producing proteins--then the patients might get better. One way to switch off a gene is to inject the cell with a siRNA (short interfering RNA) that complements the gene's product mRNA. This is called gene silencing
What came first, the plaque or the damaged neuron?
Darkfrog submitted, created time 9 months 2 weeks (www.nature.com)
By using cranial window surgery in lab mice, researchers from Harvard Medical have managed to figure out whether it is the neuron damage that causes (or at least precedes) the plaque in Alzheimer's patients or the other way around.
The results imply that it is the plaques that cause microglial accumulation, and that the microglia restrain the growth of these plaques.
The part that seems most interesting to me is the speed at which the plaques form. Very rarely do discussions of the studies talk about the speed
New support for stem cells as pit crew
Hecate submitted, created time 1 year 2 weeks (sciam.com)
Lab-mutated neurodeficient mice were injected with stem cells from 12-day-old mouse brains, resulting in marked improvement. In contrast to beliefs from just a few years ago, the injected cells didn't grow into new brain tissue. Like volunteers spicing up an old folks' home, they stimulated the damaged cells to behave in a more effective fashion.
Another revelation from this study (UC@Irvine) seems to be that the cells congregated in the damaged regions of the mouse brains. We're not sure what made them do it or what made them stay.
Conscientious people are less prone to Alzheimer's
deutschen submitted, created time 1 year 1 month (www.reuters.com)
People who lead a good clean life -- those who are conscientious, self-disciplined and scrupulous -- appear to be less likely to develop Alzheimer's disease, U.S. researchers said on Monday.
The finding is the latest from a long-running study of nearly 1,000 Catholic nuns, priests and brothers by Robert Wilson of Rush University Medical Center in Chicago. The study appeared in the Archives of General Psychiatry.
Protein that removes plaque holds promise for Alzheimer's patients
merry submitted, created time 1 year 3 months (www.cbc.ca)
Scientists from the University of Rochester Medical Centre in Rochester, N.Y., performed studies on mice with a buildup of amyloid-beta, a toxic plaque that builds up in the brains of Alzheimer's sufferers and damages them.
Cloned pigs help scientists towards a breakthrough in Alzheimer's
BIOBOSS submitted, created time 1 year 4 months (www.ku.dk)
The first pigs containing genes responsible for Alzheimer's disease will be born in Denmark in August. This event is a landmark achivement in the effort towards finding a cure for the disease.
Explaining A Link Between Strokes And Alzheimer's
cappuccion submitted, created time 1 year 5 months (www.sciencedaily.com)
It has been known for some time that the two conditions were linked, but now the Leeds team has shown how an incident of reduced oxygen to the brain -- caused by the stroke -- can leave the patient vulnerable to the gradual build-up of toxic chemicals which can cause Alzheimer's.
Elan, Wyeth Plan Advanced Trials of Drug
fiona submitted, created time 1 year 6 months (hosted.ap.org)
Ireland's Elan Corp. PLC and Wyeth of the United States said Monday they are planning advanced trials of a drug to combat Alzheimer's, the incurable brain disease that afflicts more than 20 million people worldwide.
New study zeroes in on the genetic roots of Alzheimer's
bioman submitted, created time 1 year 7 months (www.omrf.ouhsc.edu)
Scientists have known for more than a decade that individuals with a certain gene are at higher risk for developing Alzheimer’s disease. Now a new study helps explain why this is so. Approximately 15 percent of the population carries a gene that causes their bodies to produce a lipoprotein—a combination of fat and protein that transports lipids (fats) in the blood—known as apolipoprotein (Apo) E4
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