Articles with the keyword: 
A variant form of amyloid beta hinders amyloidogenesis and the development of Alzheimer's disease
piggy submitted, created time 11 months 3 weeks (www.eurekalert.org)
Alzheimer's disease is the most common form of dementia in the elderly. It is usually sporadic, but a small proportion of cases are familial, linked to mutations in the Aβ precursor protein (APP), presenilin 1 or presenilin 2 genes. The mutations identified previously increase aggregation and/or the production of Aβ, and have an autosomal dominant pattern of inheritance with complete penetrance, meaning that only one allele of the gene needs to be mutated in order to produce the disease 
Mechanisms That Prevent Alzheimer's Disease: Enzymatic Activity Plays Key Role
sea-maid submitted, created time 1 year 2 weeks (www.sciencedaily.com)
In a project involving the collaboration of several institutes, research scientists of the Johannes Gutenberg University Mainz have succeeded in gaining further insight in the functioning of endogenous mechanisms that protect against the development of Alzheimer's disease. It was found that the activity of the enzyme α-secretase is mainly responsible for the protective effect.
Headway in Understanding Alzheimer's Disease
piggy submitted, created time 1 year 1 month (www.sciencedaily.com)
Scientists at UC Santa Barbara have discovered that a protein called BAG2 is important for understanding Alzheimer's disease and may open up new targets for drug discovery. They are ready to move from studying these proteins in culture to finding out how they work with mice.
In a recently paper published in the Journal of Neuroscience, the scientists describe important activities of BAG2 in cleaning up brain cells. The protein tau is normally found in brain cells, but scientists don't know why it clumps into tangles in people with Alzheimer's disease.
Apple Juice Can Delay Onset of Alzheimer's Disease, Study Suggests
piggy submitted, created time 1 year 1 month (www.sciencedaily.com)
A growing body of evidence demonstrates that we can take steps to delay age-related cognitive decline, including in some cases that which accompanies Alzheimer's disease, according to a study published in the Journal of Alzheimer's Disease.
Thomas B
piggy submitted, created time 1 year 1 month (www.mayoclinic.org)
Researchers at Mayo Clinic have discovered the first gender-linked susceptibility gene for late-onset Alzheimer's disease.
In the Jan. 11 online edition of Nature Genetics, they report the results of their two-stage genome-wide association study of patients with Alzheimer's disease. The research showed that women who inherited two copies of a variant in the PCDH11X gene, found on the X chromosome, are at considerably greater risk of developing Alzheimer's disease
Collagen VI may help protect the brain from Alzheimer's disease
piggy submitted, created time 1 year 2 months (www.eurekalert.org)
Scientists from the Gladstone Institute of Neurological Disease (GIND), UCSF, and Stanford have discovered that a certain type of collagen, collagen VI, protects brain cells against amyloid-beta (Aβ) proteins, which are widely thought to cause Alzheimer's disease (AD). While the functions of collagens in cartilage and muscle are well established, before this study it was unknown that collagen VI is made by neurons in the brain and that it can fulfill important neuroprotective functions
How Red Wine Compounds Fight Alzheimer's Disease
piggy submitted, created time 1 year 3 months (www.sciencedaily.com)
Scientists call it the "French paradox" — a society that, despite consuming food high in cholesterol and saturated fats, has long had low death rates from heart disease. Research has suggested it is the red wine consumed with all that fatty food that may be beneficial — and not only for cardiovascular health but in warding off certain tumors and even Alzheimer's disease.
Now, Alzheimer's researchers at UCLA, in collaboration with Mt. Sinai School of Medicine in New York, have discovered how red wine may reduce the incidence of the disease. Reporting in the Nov
Ginkgo Biloba Does Not Reduce Dementia Risk, Study Shows
piggy submitted, created time 1 year 3 months (www.sciencedaily.com)
The medicinal herb Ginkgo biloba does not reduce the risk of dementia or Alzheimer's disease development in either the healthy elderly or those with mild cognitive impairment, according to a large multicenter trial led by researchers at the University of Pittsburgh School of Medicine.
Findings from the Ginkgo Evaluation of Memory (GEM) Study, which is the first to have the necessary participant numbers and monitoring years to enable measurement of G. biloba's effectiveness and safety profile in dementia prevention, were just published in the Journal of the American Medical Association
Alzheimer's Gene Slows Brain's Ability to Export Toxic Protein
piggy submitted, created time 1 year 3 months (www.sciencedaily.com)
The only known genetic risk factor for Alzheimer's disease slows down the brain's ability to export a toxic protein known as amyloid-beta that is central to the damage the disease causes, scientists have found.
The research, published Nov. 13 by the Journal of Clinical Investigation, provides new clues into the workings of a protein known as apolipoprotein E4, or ApoE4. People who carry two copies of the gene have roughly eight to ten times the risk of getting Alzheimer's disease than people who do not
Strong Education Blunts Effects of Alzheimer's Disease, Study Suggests
piggy submitted, created time 1 year 4 months (www.sciencedaily.com)
A test that reveals brain changes believed to be at the heart of Alzheimer's disease has bolstered the theory that education can delay the onset of the dementia and cognitive decline that are characteristic of the disorder.
Scientists at the Alzheimer's Disease Research Center at Washington University School of Medicine in St. Louis found that some study participants who appeared to have the brain plaques long associated with Alzheimer's disease still received high scores on tests of their cognitive ability
New Gene for Alzheimer's Discovered
lily1984 submitted, created time 1 year 8 months (www.bloomberg.com)
Scientists have discovered a gene that raises the risk of late-onset Alzheimer's disease by as much as 77 percent and provides scientists with a second genetic target for developing new treatments for the disorder.
One copy of the gene, called calcium homeostasis modulator 1, or CALHM1, increases the likelihood of late-onset Alzheimer's by 44 percent, while two copies boost the risk 77 percent. About a quarter of the population has one copy, said study author Philippe Marambaud from the Albert Einstein College of Medicine in New York. The research was published in the journal Cell
Analyst awaits data on Wyeth-Elan Alzheimer's drug
kavin submitted, created time 1 year 8 months (money.cnn.com)
By the end of the month, a Cowen and Co. analyst says, Wyeth and Elan Corp. PLC will report clinical trial data for a new kind of Alzheimer's disease treatment _ one that could slow the progress of the disease rather than fighting its symptoms.
Analyst Ian Sanderson calls the test results for bapineuzumab "one of the most anticipated phase II trials in pharmaceutical industry history." He expects Elan and Wyeth to report their findings by the end of June.
The Alzheimer's treatment market is led by four drugs: Pfizer Inc.'s Aricept, Forest Laboratories Inc
Gene silencing made practical: siRNA used to treat neurogenerative disorders in the lab
Darkfrog submitted, created time 1 year 9 months (www.jbc.org)
This abstract is about as easy to read as sixteenth-century tax law, but here's the gist: Human neurogenerative disorders, like Huntington's, Parkinson's, Alzheimer's and amyotrophic lateral sclerosis (Lou Gherig's disease) are all caused or exacerbated by the expression of mutant genes. If we switch off the genes--or at least keep them from producing proteins--then the patients might get better. One way to switch off a gene is to inject the cell with a siRNA (short interfering RNA) that complements the gene's product mRNA. This is called gene silencing
Are Immune System Molecules Brain-Builders—And Destroyers?
jane2007 submitted, created time 2 years 1 week (www.sciam.com)
Researchers stumble across immune proteins that play an unexpected—and very different—role in the brain. These findings provide a new window into the way the brain operates and why certain enigmatic disorders such as autism and Alzheimer's disease may develop, potentially paving the way for new therapies to treat them.
What came first, the plaque or the damaged neuron?
Darkfrog submitted, created time 2 years 1 month (www.nature.com)
By using cranial window surgery in lab mice, researchers from Harvard Medical have managed to figure out whether it is the neuron damage that causes (or at least precedes) the plaque in Alzheimer's patients or the other way around.
The results imply that it is the plaques that cause microglial accumulation, and that the microglia restrain the growth of these plaques.
The part that seems most interesting to me is the speed at which the plaques form. Very rarely do discussions of the studies talk about the speed
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