Articles with the keyword: 
New Gene for Alzheimer's Discovered
lily1984 submitted, created time 2 months 1 week (www.bloomberg.com)
Scientists have discovered a gene that raises the risk of late-onset Alzheimer's disease by as much as 77 percent and provides scientists with a second genetic target for developing new treatments for the disorder.
One copy of the gene, called calcium homeostasis modulator 1, or CALHM1, increases the likelihood of late-onset Alzheimer's by 44 percent, while two copies boost the risk 77 percent. About a quarter of the population has one copy, said study author Philippe Marambaud from the Albert Einstein College of Medicine in New York. The research was published in the journal Cell 
Analyst awaits data on Wyeth-Elan Alzheimer's drug
kavin submitted, created time 2 months 2 weeks (money.cnn.com)
By the end of the month, a Cowen and Co. analyst says, Wyeth and Elan Corp. PLC will report clinical trial data for a new kind of Alzheimer's disease treatment _ one that could slow the progress of the disease rather than fighting its symptoms.
Analyst Ian Sanderson calls the test results for bapineuzumab "one of the most anticipated phase II trials in pharmaceutical industry history." He expects Elan and Wyeth to report their findings by the end of June.
The Alzheimer's treatment market is led by four drugs: Pfizer Inc.'s Aricept, Forest Laboratories Inc
Gene silencing made practical: siRNA used to treat neurogenerative disorders in the lab
Darkfrog submitted, created time 3 months 23 hours (www.jbc.org)
This abstract is about as easy to read as sixteenth-century tax law, but here's the gist: Human neurogenerative disorders, like Huntington's, Parkinson's, Alzheimer's and amyotrophic lateral sclerosis (Lou Gherig's disease) are all caused or exacerbated by the expression of mutant genes. If we switch off the genes--or at least keep them from producing proteins--then the patients might get better. One way to switch off a gene is to inject the cell with a siRNA (short interfering RNA) that complements the gene's product mRNA. This is called gene silencing
Are Immune System Molecules Brain-Builders—And Destroyers?
jane2007 submitted, created time 6 months 3 days (www.sciam.com)
Researchers stumble across immune proteins that play an unexpected—and very different—role in the brain. These findings provide a new window into the way the brain operates and why certain enigmatic disorders such as autism and Alzheimer's disease may develop, potentially paving the way for new therapies to treat them.
What came first, the plaque or the damaged neuron?
Darkfrog submitted, created time 6 months 4 weeks (www.nature.com)
By using cranial window surgery in lab mice, researchers from Harvard Medical have managed to figure out whether it is the neuron damage that causes (or at least precedes) the plaque in Alzheimer's patients or the other way around.
The results imply that it is the plaques that cause microglial accumulation, and that the microglia restrain the growth of these plaques.
The part that seems most interesting to me is the speed at which the plaques form. Very rarely do discussions of the studies talk about the speed
sumsung submitted, created time 10 months 3 weeks (www.pnas.org)
Amyloid β-protein (Aβ) oligomers may be the proximate neurotoxins in Alzheimer's disease (AD). Recently, to elucidate the oligomerization pathway, we studied Aβ monomer folding and identified a decapeptide segment of Aβ.
Molecular basis for passive immunotherapy of Alzheimer's disease
benjiamin submitted, created time 11 months 1 week (www.pnas.org)
Amyloid aggregates of the amyloid-β(Aβ) peptide are implicated in the pathology of Alzheimer's disease. Anti-Aβ monoclonal antibodies (mAbs) have been shown to reduce amyloid plaques in vitro and in animal studies.
Eating fish good for heart but bad for environment
Reviver submitted, created time 1 year 3 weeks (www.reutershealth.com)
study published in June in the American Heart Association journal Circulation said a diet with liberal servings of fish, nuts and seeds rich in such nutrients can help lower a person's blood pressure. Other studies have shown benefits to eye and brain development and preventing heart disease, Alzheimer's disease and eye disorders.
sumsung submitted, created time 1 year 1 month (www.pnas.org)
We have tested a hypothesis that the natural product curcuminoids, which has epidemiologic and experimental rationale for use in AD, may improve the innate immune system and increase amyloid- (A) clearance from the brain of patients with sporadic Alzheimer's disease (AD).
New risk factors discovered for Alzheimer's disease
bianjie submitted, created time 1 year 2 months (www.blackwellpublishing.com)
A recent study in Journal of Neuroimaging suggests that cognitively normal adults exhibiting atrophy of their temporal lobe or damage to blood vessels in the brain are more likely to develop Alzheimer's disease. Older adults showing signs of both conditions were seven-times more likely to develop Alzheimer's than their peers.
Cloned pigs help scientists towards a breakthrough in Alzheimer's
BIOBOSS submitted, created time 1 year 2 months (www.ku.dk)
The first pigs containing genes responsible for Alzheimer's disease will be born in Denmark in August. This event is a landmark achivement in the effort towards finding a cure for the disease.
Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases
addict submitted, created time 1 year 2 months (www.nature.com)
Aggregation of hyperphosphorylated tau is one of the characteristic neuropathological lesions of Alzheimer's disease and other neurodegenerative disorders. Pharmacological modulation of tau hyperphosphorylation might represent a valid and feasible therapeutic strategy for such disorders. Here, we consider recent evidence supporting the validity of the three most relevant kinases affecting tau hyperphosphorylation — GSK3beta, CDK5 and ERK2 — as drug targets and describe progress in the design of inhibitors for these kinases.
Alzheimer's Enzyme Acts As A Tumor Suppressor
Cindy submitted, created time 1 year 2 months (www.sciencedaily.com)
Researchers at Burnham Institute for Medical Research ("Burnham") have provided the first evidence that gamma-secretase, an enzyme key to the progression of Alzheimer's, acts as a tumor suppressor by altering the pathway of epidermal growth factor receptor (EGFR), a potential treatment target for cancer. Expedited to publication online by Proceedings of the National Academy of Sciences, these findings reveal a limitation of targeting gamma-secretase for treatment of Alzheimer's and potentially other diseases.
Mechanisms That May Unlock Answers To Alzheimer's Disease Found By MU Researchers
diggman submitted, created time 1 year 2 months (www.medicalnewstoday.com)
"Four million people in the United States and 15 to 20 million people worldwide are affected by Alzheimer's disease. These numbers are likely to triple by 2050 due to the fact that 24 percent of the population will be more than 65 years old. In their attempt to combat the disease, two University of Missouri-Columbia professors have identified new mechanisms that could have major implications in the development of treatments for the disease.
Blocking Stress Protein Decreases Alzheimer's Peptide In Mice
diggman submitted, created time 1 year 2 months (www.medicalnewstoday.com)
Scientists revealed in November 2006 that stress increases production in mice of a brain peptide critical to Alzheimer's disease. Now the same group has shown that blocking a different brain peptide slows the stress-induced increase, opening a new door to treatment. Researchers from Washington University School of Medicine in St. Louis report the results online this week in the Proceedings of the National Academy of Sciences.
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