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1

Long-Term Antibiotic Use Affects "Good" Gut Bacteria

sea-maid submitted, created time 1 day 22 hours (health.yahoo.com)

Antibiotic treatment, especially when prolonged or repeated, may have a negative impact on beneficial bacteria that live in the gut, according to a new study.

Gut bacteria play helpful roles in various aspects of human nutrition, metabolism and immune responses, experts note.

Researchers focused on the widely-used antibiotic ciprofloxacin, prescribed for a number of bacteria-caused conditions, including urinary tract infections. It has been believed that ciprofloxacin causes only modest harm to beneficial bacteria in the body.

In this study, Stanford University's Dr

10

Antibacterial drugs: New paths to beating bacteria

sea-maid submitted, created time 2 weeks 5 days (www.nature.com)

The need for new drugs to combat multidrug-resistant bacteria remains pressing. Now, two recent papers published in Science describe novel agents that target different mechanisms to currently approved antibacterials, which may help tackle this challenge.

The first study, by Haydon and colleagues, set out to target bacterial cell division. FtsZ is an essential bacterial protein that undergoes GTP-dependent polymerization to form the Z ring — the site of cell division — promoting the sequential recruitment of additional proteins that are vital to the process

7

CDC Campaign Targets MRSA Infections

jerry submitted, created time 2 months 1 week (health.usnews.com)

A national campaign to teach parents how to protect kids from skin infections caused by dangerous methicillin-resistant Staphylococcus aureus (MRSA) bacteria was launched this week by the US Centers for Disease ...

8

Gentle approach could cripple drug-resistant bugs

sea-maid submitted, created time 2 months 4 weeks (www.newscientist.com)

Taking a softly, softly approach to wiping out infection might be the way to beat the evolution of drug resistance in bacteria.

This new technique involves blocking the tularaemia bacterium's ability to sense human hormones. Although testing in human subjects is at least five years off, the bacteria's ability to kill mice was "crippled" by the alterations.

9

New antibiotic beats superbugs at their own game

kavin submitted, created time 4 months 2 weeks (esciencenews.com)

The problem with antibiotics is that, eventually, bacteria outsmart them and become resistant. But by targeting the gene that confers such resistance, a new drug may be able to finally outwit them. Rockefeller University scientists tested the new drug, called Ceftobiprole, against some of the deadliest strains of multidrug-resistant Staphylococcus aureus (MRSA) bacteria, which are responsible for the great majority of staphylococcal infections worldwide, both in hospitals and in the community

9

The emergence of Stenotrophomonas maltophilia ...exaggerated

sea-maid submitted, created time 5 months 1 week (www.bmj.com)

Headlines about S maltophilia, including "no antibiotics can stop it" and "rising death toll in hospitals" are unfounded, write Georgia Duckworth and Alan Johnson, from the Health Protection Agency's Centre for Infections in London. In fact, they say, S maltophilia infections are relatively rare compared to infections caused by bacteria such as meticillin resistant Staphylococcus aureus (MRSA).

12

Resistance to drugs responsible for half of deaths from infections

sea-maid submitted, created time 5 months 1 week (www.bmj.com)

Multidrug resistant bacteria are responsible for about half of the 37,000 deaths a year in the 27 member states of the European Union that are caused by infections associated with health care, show the preliminary results of research from the European Centre for Disease Prevention and Control in Stockholm.

6

Antibiotic Alligator: Promising proteins lurk in reptile blood

jiangyun submitted, created time 7 months 1 week (www.sciencenews.org)

Researchers hunting for new antibiotics might get some aid from gator blood. Scientists are zeroing in on snippets of proteins found in American alligator blood that kill a wide range of disease-causing microbes and bacteria, including the formidable MRSA or methicillin-resistant Staphylococcus aureus.

7

Drug-resistant tuberculosis plagues the former U.S.S.R.

Darkfrog submitted, created time 8 months 3 weeks (www.nytimes.com)

In 1994, experts believed that drug-resistant TB would not become a mainstream problem, that it would be restricted to immunosuppressed patients. It's in the world, though, and we have to deal with it.

Strains of tuberculosis resistant to first-line drugs are increasing in prevalence in the countries that once comprised the Soviet Union. The antibiotics to correct are one hundred times more expensive than standard and must be taken for two years.

6

DNA Pollution May Be Spawning Killer Microbes

Sue Wu submitted, created time 9 months 4 days (discovermagazine.com)

Rogue genetic snippets spread antibiotic resistance all over the environment. But where do they come from in the first place?

6

Bug slime's surprising effect on disease

DanyC submitted, created time 9 months 2 weeks (www.newscientist.com)

The decision to make slime or not can depend on "quorum sensing," in which bacteria detect how dense the colony is. Carey Nadell at Princeton University and colleagues designed a computer model of biofilms and found that if some bacteria turn off slime production when density is great and focus on reproducing, they can burst out of the biofilm and proliferate. But after a while they are suffocated when the bacteria that kept making slime mount up. The study unveils a key difference between acute and chronic infections.

6

HIV and TB emerge as African epidemic

biosunny submitted, created time 1 year 2 weeks (www.upi.com)

CAPE TOWN, South Africa, Nov. 2 (UPI) -- Cape Town, South Africa, is among the worst cities in the region affected by a epidemic of HIV and drug-resistant tuberculosis.
The BBC in Cape Town reported that children in the city’s slums are 100 times more likely to contract TB than elsewhere in the world.

6

"Drug resistant" doesn't mean what it used to

Darkfrog submitted, created time 1 year 5 months (www.nytimes.com)

It means more. According to the World Health Organization, strains of drug-resistant tuberculosis show themselves more resistant to more kinds of drugs than even as late as 1994. The study is based on information collected in 2004.

6

Maggots munch on antibiotic-resistant bacteria

Darkfrog submitted, created time 1 year 6 months (www.nature.com)

First leeches for amputees, now maggots for diabetic patients' infected lesions. They may be creepy and crawly, but these industrious larvae are chowing down on harmful bacteria. Many mysteries remain: Do these bugs secrete antibacterial ichor or do they just eat the dead flesh? A larger study is planned.

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