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1

Long-Term Antibiotic Use Affects "Good" Gut Bacteria

sea-maid submitted, created time 2 days 4 minutes (health.yahoo.com)

Antibiotic treatment, especially when prolonged or repeated, may have a negative impact on beneficial bacteria that live in the gut, according to a new study.

Gut bacteria play helpful roles in various aspects of human nutrition, metabolism and immune responses, experts note.

Researchers focused on the widely-used antibiotic ciprofloxacin, prescribed for a number of bacteria-caused conditions, including urinary tract infections. It has been believed that ciprofloxacin causes only modest harm to beneficial bacteria in the body.

In this study, Stanford University's Dr

9

Follow-up data on the effects of antibiotics in pregnant women

jerry submitted, created time 1 month 6 days (www.thelancet.com)

Long-term follow-up data on the effects of antibiotics in pregnant women experiencing premature labour and the developmental effects on their children are published in the ORACLE children study. The original trial published in 2001 investigated the effect of two antibiotics given around preterm labor. The follow-up findings have important implications for the clinical management of pregnant women experiencing preterm birth......

8

Gentle approach could cripple drug-resistant bugs

sea-maid submitted, created time 2 months 4 weeks (www.newscientist.com)

Taking a softly, softly approach to wiping out infection might be the way to beat the evolution of drug resistance in bacteria.

This new technique involves blocking the tularaemia bacterium's ability to sense human hormones. Although testing in human subjects is at least five years off, the bacteria's ability to kill mice was "crippled" by the alterations.

9

New antibiotic beats superbugs at their own game

kavin submitted, created time 4 months 2 weeks (esciencenews.com)

The problem with antibiotics is that, eventually, bacteria outsmart them and become resistant. But by targeting the gene that confers such resistance, a new drug may be able to finally outwit them. Rockefeller University scientists tested the new drug, called Ceftobiprole, against some of the deadliest strains of multidrug-resistant Staphylococcus aureus (MRSA) bacteria, which are responsible for the great majority of staphylococcal infections worldwide, both in hospitals and in the community

9

The emergence of Stenotrophomonas maltophilia ...exaggerated

sea-maid submitted, created time 5 months 1 week (www.bmj.com)

Headlines about S maltophilia, including "no antibiotics can stop it" and "rising death toll in hospitals" are unfounded, write Georgia Duckworth and Alan Johnson, from the Health Protection Agency's Centre for Infections in London. In fact, they say, S maltophilia infections are relatively rare compared to infections caused by bacteria such as meticillin resistant Staphylococcus aureus (MRSA).

12

Resistance to drugs responsible for half of deaths from infections

sea-maid submitted, created time 5 months 1 week (www.bmj.com)

Multidrug resistant bacteria are responsible for about half of the 37,000 deaths a year in the 27 member states of the European Union that are caused by infections associated with health care, show the preliminary results of research from the European Centre for Disease Prevention and Control in Stockholm.

10

Penicillin and meningococcal disease: case-control study

jerry submitted, created time 6 months 1 week (student.bmj.com)

This study was performed to ascertain whether penicillin prescribed by a general practitioner before admission to hospital improved children’s outcomes.
Children who were given parenteral penicillin by a general practitioner had more severe disease on reaching hospital than those who were not given penicillin before admission. The association with poor outcome may be because children who are more severely ill are being given penicillin before admission.

7

Tuberculosis's Battle ---New Strategy

Sue Wu submitted, created time 7 months 4 hours (www.sciam.com)

Israeli researchers find that feeding nutrients to dormant bacteria gives them a one hour window in which to kill them with antibiotics.

7

Sleep Deprivation for Germs

davidd submitted, created time 7 months 1 day (sciencenow.sciencemag.org)

Most antibiotics kill only microbes that are growing and multiplying, leaving untouched a select few that are hibernating. A new study suggests that a dose of the right nutrients can awaken these bacteria for just long enough to kill them with antibiotics.

6

Antibiotic Alligator: Promising proteins lurk in reptile blood

jiangyun submitted, created time 7 months 1 week (www.sciencenews.org)

Researchers hunting for new antibiotics might get some aid from gator blood. Scientists are zeroing in on snippets of proteins found in American alligator blood that kill a wide range of disease-causing microbes and bacteria, including the formidable MRSA or methicillin-resistant Staphylococcus aureus.

5

Bacteria in Soil Eat Antibiotics

jane2007 submitted, created time 7 months 2 weeks (online.wsj.com)

Harvard researchers have discovered hundreds of germs in soil that literally gobble up antibiotics, able to thrive with the potent drugs as their sole source of nutrition. But that's not entirely all bad news.

7

Drug-resistant tuberculosis plagues the former U.S.S.R.

Darkfrog submitted, created time 8 months 3 weeks (www.nytimes.com)

In 1994, experts believed that drug-resistant TB would not become a mainstream problem, that it would be restricted to immunosuppressed patients. It's in the world, though, and we have to deal with it.

Strains of tuberculosis resistant to first-line drugs are increasing in prevalence in the countries that once comprised the Soviet Union. The antibiotics to correct are one hundred times more expensive than standard and must be taken for two years.

6

DNA Pollution May Be Spawning Killer Microbes

Sue Wu submitted, created time 9 months 4 days (discovermagazine.com)

Rogue genetic snippets spread antibiotic resistance all over the environment. But where do they come from in the first place?

7

Sounding the Alarm: Multiple Functions of Host Defense Peptides

davidd submitted, created time 9 months 2 weeks (www.nature.com)

The capacity of the skin and other organs to resist infection depends on the innate production of molecules known as antimicrobial peptides. Emerging evidence suggests that some of these peptides are important to immune defense by acting not only as natural antibiotics but also as cell-signaling molecules.

5

What makes one bacterium so deadly

yangjane submitted, created time 1 year 4 days (www.sciencenews.org)

Scientists have discovered some of the most aggressive antibiotic-resistant staph infections gain their advantage with a molecule that punctures the immune cells trying to fight off the bacteriaCommunity-associated MRSA (CA-MRSA). Understanding the role of this molecule in methicillin-resistant Staphylococcus aureus (MRSA) could lead to new therapies for the notoriously hard-to-treat, and sometimes fatal, skin infection.
This article is about antibiotic-resistant staph infections. It give us a question how to use antibiotic and how to prevent the Staphylococcus aureus.

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