Alzheimer's Gene Slows Brain's Ability to Export Toxic Protein

piggy submitted, created time 1 week 1 day (www.sciencedaily.com)

The only known genetic risk factor for Alzheimer's disease slows down the brain's ability to export a toxic protein known as amyloid-beta that is central to the damage the disease causes, scientists have found.

The research, published Nov. 13 by the Journal of Clinical Investigation, provides new clues into the workings of a protein known as apolipoprotein E4, or ApoE4. People who carry two copies of the gene have roughly eight to ten times the risk of getting Alzheimer's disease than people who do not

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Brain Apolipoprotein E: an Important Regulator of Food Intake in Rats

jerry submitted, created time 3 months 6 days (diabetes.diabetesjournals.org)

The worldwide prevalence of obesity is increasing at an alarming rate, along with the associated increased rates of type 2 diabetes, heart disease, and some cancers. While efforts to address environmental factors responsible for the recent epidemic must continue, investigation into the anorectic functions of potential molecules they present in this paper, such as apolipoprotein (apo) E, offers exciting possibilities for future development of successful anti-obesity therapies

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Alzheimer's Risk Factor Also Aids HIV

sea-maid submitted, created time 4 months 4 weeks (www.sciencemag.org)

The defective lipid carrier apolipoprotein E4 (apoE4) has accumulated a nasty record. Not only are people who have the gene for apoE4 famously predisposed to Alzheimer's disease, but the same risk factor can also worsen several nervous system disorders and promote cardiovascular disease. A study out this week suggests that apoE4 also hastens the death of people infected with HIV, possibly by allowing the virus easy entry into cells.

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Aβ, tau and ApoE4 in Alzheimer's disease: the axonal connection

amanda submitted, created time 1 year 7 months (www.sciencedirect.com)

"Mutations in amyloid precursor protein (APP), tau and apolipoprotein E4 (ApoE4) lead to Alzheimer's disease (AD) or related pathologies. Pathogenesis and interactions between these pathways have been studied in mouse models."

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