Recurrent axon collaterals underlie facilitating synapses between cerebellar Purkinje cells

richard submitted, created time 1 year 3 weeks (www.pnas.org)

Morphological studies have provided ample evidence for synaptic connections between cerebellar Purkinje cells (PCs), but the functional properties of these synapses remain elusive. We report on direct recordings of synaptically connected PCs in mice cerebellar slices.

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Sumoylation in axons triggers retrograde transport of the RNA-binding protein La

bianjie submitted, created time 1 year 3 months (www.pnas.org)

A surprisingly large population of mRNAs has been shown to localize to sensory axons, but few RNA-binding proteins have been detected in these axons. These axonal mRNAs include several potential binding targets for the La RNA chaperone protein.

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Gap junctions on hippocampal mossy fiber axons demonstrated by thin-section electron microscopy and freeze-fracture replica immunogold labeling

sumsung submitted, created time 1 year 4 months (www.pnas.org)

Gap junctions have been postulated to exist between the axons of excitatory cortical neurons based on electrophysiological, modeling, and dye-coupling data. Here, we provide ultrastructural evidence for axoaxonic gap junctions in dentate granule cells.

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Bidirectional Eph–ephrin signaling during axon guidance

amanda submitted, created time 1 year 6 months (www.sciencedirect.com)

"Ephrins are cell-surface tethered guidance cues that bind to Eph receptor tyrosine kinases in trans on opposing cells. In the developing nervous system, the Eph–ephrin signaling system controls a large variety of cellular responses including contact-mediated attraction or repulsion, adhesion or de-adhesion, and migration. Eph–ephrin signaling can be bidirectional, and is subject to modulation by ectodomain cleavage of ephrins and by Eph–ephrin endocytosis

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Aβ, tau and ApoE4 in Alzheimer's disease: the axonal connection

amanda submitted, created time 1 year 7 months (www.sciencedirect.com)

"Mutations in amyloid precursor protein (APP), tau and apolipoprotein E4 (ApoE4) lead to Alzheimer's disease (AD) or related pathologies. Pathogenesis and interactions between these pathways have been studied in mouse models."

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Neuronal death: where does the end begin?

athena submitted, created time 1 year 7 months (www.sciencedirect.com)

"Neurodegenerative disorders involve death of cell bodies, axons, dendrites and synapses, but it is surprisingly difficult to determine the spatiotemporal sequence of events and the causal relationships among these events. "

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Netrin signaling leading to directed growth cone steering

amanda submitted, created time 1 year 7 months (www.sciencedirect.com)

"In the developing nervous system, nerve cells and axons respond to various attractive and repulsive guidance cues while traveling to their final destination. Netrins are bifunctional guidance cues that attract several classes of axons but repel others. The response of an axon to netrins is dictated by the composition of netrin receptors on the cell surface and the internal state of the growth cone. Recent analyses have identified several signal transduction pathways that contribute to netrin-mediated guidance

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