Smad1 as a Biomarker for Diabetic Nephropathy

A search for biomarkers for early detection of colorectal cancer

william submitted, created time 1 year 1 month (www.eurekalert.org)

Using two-dimensional gel electrophoresis, 27 differentially expressed proteins were identified in colorectal adenoma, compared with individual-matched normal mucosa and cancer tissue. In those proteins, the differential expression of two novel proteins, mimecan and thioredoxin domain-containing protein 5 (TXNDC5), were validated by Western-blot. This study clearly demonstrated that absence of mimecan and up-regulation of TXNDC5 were involved in the early development of colorectal cancer.

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Cell receptor may lead to new 'biomarker' for pancreatic cancer

BIOBOSS submitted, created time 1 year 4 months (www.eurekalert.org)

A research team led by University of Cincinnati scientists has identified a potential biological target for pancreatic cancer, a finding they say could help scientists better understand -- and eventually treat -- the disease that kills more than 33,000 people each year.

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Every moment counts: Predicting treatment responses earlier for brain tumor patients

daphne submitted, created time 1 year 5 months (www.eurekalert.org)

First-ever study shows FLT-PET is powerful imaging biomarker, predictor of treatment response, outcome, say UCLA Researchers at SNM's 54th Annual Meeting June 2�n Washington, D.C. Using metabolic or molecular imaging to measure brain tumor patients' response to treatment is a powerful predictor of survival, notes a first-of-its-kind study presented at the 54th Annual Meeting of SNM, the world's largest society for molecular imaging and nuclear medicine professionals.

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Shaping the future of biomarker research in breast cancer to ensure clinical relevance

dovechocolate submitted, created time 1 year 6 months (www.nature.com)

Each year, over 200,000 people are diagnosed with breast cancer in the United States. Although the use of biomarkers has the potential to guide preventive interventions and improve survival and quality of life, there have been few successes and many disappointments. In November 2005, the National Breast Cancer Coalition Fund convened a conference aimed at developing a patient-centred, strategic approach to breast cancer biomarker research

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Expression profiling of Ral-depleted bladder cancer cells identifies RREB-1 as a novel transcriptional Ral effector

sciencebaby submitted, created time 1 year 6 months (www.nature.com)

Although the monomeric GTPases RalA and RalB have been shown to regulate a variety of transcription factors, little is known regarding the differences or similarities in transcriptional programs regulated by RalA compared to RalB. Further, the association of these transcriptional pathways to human carcinogenesis and progression remains unclear. Here, we studied the role of RalA and/or RalB in transcriptional regulation by combining short interfering RNA depletion of Ral with gene expression profiling via microarray in the human bladder cancer cell line, UMUC-3.

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Michael J. Fox Foundation Continues To Lead Search For Biomarkers Of Parkinson's Disease

collapsar submitted, created time 1 year 7 months (www.medicalnewstoday.com)

The Michael J. Fox Foundation today announced the launch of Biomarkers 2007, a two-year, $2-million funding program dedicated to research toward the discovery of an objective biomarker, or "biological fingerprint," of Parkinson's disease. This is the third funding round under the Foundation's Biomarkers program designed to drive discovery of this crucial resource, which the Parkinson's field currently lacks.

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