Studies to find better ways to preserve human eggs, ovarian tissue under way

bioman submitted, created time 1 year 5 months (www.eurekalert.org)

The goal is to make human eggs, ovarian tissue, blood vessels, even whole organs available when needed.

To get there, researchers are directly comparing slow-freezing techniques, used successfully for decades to preserve sperm and embryos, to a more rapid method of cryopreservation that transforms tissues into durable glass-like structures.

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The osteogenicity of implanted engineered bone constructs is related to the density of clonogenic bone marrow stromal cells

BIOBOSS submitted, created time 1 year 7 months (www3.interscience.wiley.com)

Reproducible osteogenicity is a key requirement for the clinical use of bone substitutes based on bone marrow stromal cells (BMSCs) and three-dimensional (3D) scaffolds. In this study we addressed whether a minimal cell density is required for ectopic osteogenicity of constructs generated using a recently developed perfusion system for seeding and culturing human BMSCs on 3D scaffolds.

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Cell-Based Bone Tissue Engineering

diggman submitted, created time 1 year 8 months (medicine.plosjournals.org)

Until recently, the use of autologous bone grafts has been the number one choice for bone repair and regeneration [1–5]. A patient's own bone lacks immunogenicity and provides bone-forming cells, which are directly delivered at the implant site. autologous bone grafts recruit mesenchymal cells and induce them to differentiate into osteogenic cells through exposure to osteoinductive growth factors. Although there are many advantages to using autologous bone, there are major drawbacks to the harvesting procedure, and for centuries there has been a search for alternatives

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