Early Stage Bone Cells Produce Potential Estrogen Substitute,

kavin submitted, created time 4 months 1 week (www.medicalnewstoday.com)

Cells on their way to forming bone also produce an estrogen-like substance that mimics the naturally occurring female sex hormone estradiol, investigators at the Yale School of Medicine reported Monday in the online edition of the Proceedings of the National Academy of Sciences.

Researchers hope such a molecule might provide some of the benefits but, hopefully, not the health risk of traditional hormonal therapies for menopause and bone loss.

Researchers in the laboratories of Thomas L

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Cell-Based Bone Tissue Engineering

diggman submitted, created time 1 year 8 months (medicine.plosjournals.org)

Until recently, the use of autologous bone grafts has been the number one choice for bone repair and regeneration [1–5]. A patient's own bone lacks immunogenicity and provides bone-forming cells, which are directly delivered at the implant site. autologous bone grafts recruit mesenchymal cells and induce them to differentiate into osteogenic cells through exposure to osteoinductive growth factors. Although there are many advantages to using autologous bone, there are major drawbacks to the harvesting procedure, and for centuries there has been a search for alternatives

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