Articles with the keyword: 
Stem Cell 'Daughters' Lead To Breast Cancer
sea-maid submitted, created time 1 year 1 month (www.sciencedaily.com)
Walter and Eliza Hall Institute scientists have found that a population of breast cells called luminal progenitor cells are likely to be responsible for breast cancers that develop in women carrying mutations in the gene BRCA1. 
Common Virus Kills Cancer Stem Cells
sea-maid submitted, created time 1 year 4 months (www.sciencedaily.com)
Dalhousie Medical School cancer researcher Dr. Patrick Lee has proven that a common virus can infect and kill breast cancer stem cells. This breakthrough finding is published in the current issue of Molecular Therapy, the journal of the American Society of Gene Therapy.
Breakthrough model for human cancer may improve development of cancer drugs
piggy submitted, created time 1 year 4 months (www.eurekalert.org)
AVEO Pharmaceuticals, Inc., a biopharmaceutical company leveraging breakthrough discoveries in cancer biology to discover, develop and commercialize targeted oncology therapies, today announced findings from its novel human-in-mouse (HIM) cancer model system, in which AVEO successfully created invasive human tumors from primary human breast tissue. These tumors are placed in test mice, where they develop over time, mimicking the progress and responses of human tumors. The findings were published this week in the early edition of the Proceedings of the National Academy of Sciences.
Penn Study Examines Power of Exercise to Prevent Breast Cancer
piggy submitted, created time 1 year 5 months (www.uphs.upenn.edu)
A new federally funded University of Pennsylvania School of Medicine study aims to learn whether women at high risk of breast cancer can use exercise to meaningfully reduce their risk of getting the disease. Building on evidence that shows that reducing estrogen in the body reduces cancer risk and that elite female athletes experience a drop in estrogen levels that often causes them to stop ovulating and menstruating, the WISER Sister trial will investigate two different levels of regular treadmill exercise as a possible intervention for breast cancer risk reduction.
Pfizer ends trial early for cancer drug Sutent
piggy submitted, created time 1 year 5 months (finance.yahoo.com)
Pfizer Inc. said Thursday it stopped a late-stage study of the cancer drug Sutent to treat a form of advanced breast cancer but will continue examining the drug in several other mid- and late-stage trials.
The drug maker said it stopped a study that compared the results of Sutent with those of capecitabine when each was used alone in patients who had already tried standard treatments
New Test May Predict Spread of Breast Cancer
sea-maid submitted, created time 1 year 5 months (www.sciencedaily.com)
Scientists at Albert Einstein College of Medicine of Yeshiva University have previously shown that the co-mingling of three cell types can predict whether localized breast cancer will spread throughout the body. Now, a collaborative study led by investigators at New York-Presbyterian Hospital/Weill Cornell Medical Center, has produced a test for metastasis that could help doctors precisely identify which patients should receive aggressive therapy.
Light reveals breast tumor oxygen status
piggy submitted, created time 1 year 5 months (www.eurekalert.org)
Light directed at a breast tumor through a needle can provide pathologists with biological specifics of the tumor and help oncologists choose treatment options that would be most effective for that individual patient.
Duke University bioengineers have developed a light-based system that can quickly and easily provide important information about oxygen levels within a tumor while it is still in place. The new system, based on diffuse reflectance spectroscopy, gives researchers important clues about the tumor by interpreting how the light is either reflected back from the tumor or absorbed
Promiscuous antibody targets cancer
piggy submitted, created time 1 year 5 months (www.nature.com)
Researchers have challenged an old immunological dogma — that an antibody can bind to only a single target or antigen — by engineering an antibody to bind tightly to two distinct proteins.
The antibody, described in Science1, blocks two proteins: vascular endothelial growth factor (VEGF) and human epidermal growth factor receptor 2 (HER2). VEGF is thought to promote growth in tumors, and HER2 is highly expressed by some aggressive breast tumors
Aberrant and ordinary embryonic pathways in leukemic stem cells
sea-maid submitted, created time 1 year 5 months (www.nature.com)
A growing body of research in breast cancer, leukemia and brain cancer shows that cancer stem cells co-opt the pathways of regular stem cells to maintain themselves and resist treatments. Two recent studies in acute myeloid leukemia have used very different techniques that each point to the likelihood of uncovering strategies to target cancer stem cells while sparing healthy stem cells.
Twin Nanoparticle Shown Effective at Targeting and Killing Breast Cancer Cells
sea-maid submitted, created time 1 year 5 months (www.sciencedaily.com)
Breast cancer patients face many horrors, including those that arise when fighting the cancer itself. Medications given during chemotherapy can have wicked side effects, including vomiting, dizziness, anemia and hair loss. These side effects occur because medications released into the body target healthy cells as well as tumor cells.
Researchers from Brown University have developed a twin nanoparticle that specifically targets only the Her-2 cancer cell, delivering tiny doses of cisplasin directly to the malignant cell.
Small molecules block cancer gene
piggy submitted, created time 1 year 5 months (www.bcm.edu)
Finding molecules that block the activity of the oncogene Stat3 (signal transducer and activator of transcription) required screening literally millions of compounds, using computers that compared the structure of the cancer-causing gene to those of the small molecules, said a Baylor College of Medicine researcher in a report that appears in the current online issue of the journal PLoS One.
It was worth the effort, says Dr. David J
Red Wine or White? Both Equal Offenders in Breast-Cancer Risk
sea-maid submitted, created time 1 year 5 months (www.sciencedaily.com)
The largest study of its kind to evaluate the effect of red versus white wine on breast-cancer risk concludes that both are equal offenders when it comes to increasing breast-cancer risk. The results of the study, led by researchers at Fred Hutchinson Cancer Research Center, were published in the March issue of Cancer Epidemiology, Biomarkers and Prevention.
A new genetic hotspot for breast cancer
sea-maid submitted, created time 1 year 6 months (www.sciencedaily.com)
Vanderbilt-Ingram Cancer Center investigators have identified a new genetic hotspot for breast cancer.
Genetic hotspot for breast cancer risk
piggy submitted, created time 1 year 6 months (www.eurekalert.org)
Vanderbilt-Ingram Cancer Center investigators have identified a new genetic hotspot for breast cancer.
Reporting this week in Nature Genetics, Wei Zheng, M.D., Ph.D, and colleagues have identified a region on chromosome 6 that is strongly associated with breast cancer susceptibility in Asian women. This genetic locus may help guide efforts to find the specific genes linked with sporadic – or non-inherited – forms of the disease, the authors suggest.
Breast cancer is one of the most common cancer types among women worldwide
Statin therapy ineffective in breast cancer prevention
piggy submitted, created time 1 year 7 months (www.eurekalert.org)
Laboratory work in animals showed limited activity when statins were given to prevent breast cancer, according to a report in the February issue of Cancer Prevention Research, a journal of the American Association for Cancer Research.
Statins, sold under brand names like Lipitor and Zocor, are primarily given to lower cholesterol and prevent heart disease, and prominent cardiologists almost universally agree that their use has changed the landscape.
The use of these drugs in cancer prevention has been more controversial
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