Articles with the keyword: 
kavin submitted, created time 4 months 3 weeks (content.nejm.org)
Much has been learned about the potential of the immune system to control cancer and the various ways that immunotherapy can boost the potential of the immune system for the benefit of the patient. This knowledge has stimulated the invention of many new therapeutic antibodies, cell-based treatments, and vaccines, which are starting to be used in clinical practice, either alone or in various combinations. These new therapies are expected to result in improved cancer treatment and, eventually, the prevention of cancer. 
kavin submitted, created time 6 months 1 day (www.ncbi.nlm.nih.gov)
Most head and neck cancers are squamous cell carcinomas that develop in the upper aerodigestive epithelium after exposure to carcinogens such as tobacco and alcohol. The authors review the epidemiology, molecular pathogenesis, diagnosis and staging, and the latest multimodal management of squamous cell carcinoma of the head and neck.
Involvement of ERK activation for cancer cell killing
manojkbhat submitted, created time 1 year 1 month (www.febsletters.org)
In general, the activation of extracellular recognition kinase (ERK) cascade is implicated in exerting tumorigenic effects. Conversely, recent studies suggest that ERK activation may also have role in DNA-damage induced apoptosis. Here we observed an essential requirement of ERK activation in carboplatin induced apoptosis in cervical cancer SiHa and CaSki cells. Under similar treatment conditions p53 was also involved in Carboplatin induced apoptosis in these cells
jiangyun submitted, created time 1 year 2 months (genomebiology.com)
Perturbations in cell-cell interactions are a key feature of cancer. However, little is known about the systematic effects of cell-cell interaction on global gene expression in cancer.
Reviver submitted, created time 1 year 4 months (www.molecular-cancer.com)
"Researchers demonstrate a novel therapeutic strategy that induces a significant increase in pancreas cancer cell death. This strategy highlights a new potential target for the treatment of pancreas cancer, which has little in the way of effective treatments."
Cell Toxin Found To Inhibit Survival Proteins In Cancer Cells Has New Application
broadcast submitted, created time 1 year 4 months (www.medicalnewstoday.com)
A chemically-modified version of a mitochondrial toxin long used to control species of invasive fish in lakes has been found to selectively inhibit two "survival proteins" in cancer cells. The research is a first step toward developing a molecularly-targeted drug that could eliminate cellular-level resistance to multiple types of chemotherapy and radiation therapy found in many types of cancers.
crackpot submitted, created time 1 year 5 months (www.cancercell.org)
“Cytotoxic drug resistance is a major cause of cancer treatment failure. They report an RNA interference screen to identify genes influencing sensitivity of different cancer cell types to chemotherapeutic agents. A set of genes whose targeting leads to resistance to paclitaxel is identified, many of which are involved in the spindle assembly checkpoint. Silencing these genes attenuates paclitaxel-induced mitotic arrest and induces polyploidy in the absence of drug
New Contributor To Aggressive Cancers Found
penguin submitted, created time 1 year 5 months (www.sciencedaily.com)
Mutations in the cell adhesion molecule known as integrin alpha 7 (integrin α7) lead to unchecked tumor cell proliferation and a significantly higher incidence in cancer spread, or metastasis, in several cancer cell lines, report researchers at the University of Pittsburgh School of Medicine in a study being published recently in the Journal of the National Cancer Institute. These findings suggest that integrin α7 represents an important new target for cancer therapy and prevention.
NOW PLAYING: CELL MIGRATION LIVE!
diggman submitted, created time 1 year 5 months (www.hopkinsmedicine.org)
Johns Hopkins researchers have found a way to directly observe cell migration -- in real time and in living tissue. In a report in the June 5 issue of Developmental Cell, the scientists say their advance could lead to strategies for controlling both normal growth and the spread of cancer, processes that depend on the programmed, organized movement of cells across space.
[FW]FDA Approves Kidney Cancer Drug
DanyC submitted, created time 1 year 5 months (www.foxnews.com)
Torisel, which contains the active ingredient temsirolimus, was approved based on a study that showed the drug prolonged survival of patients with renal cell carcinoma. The drug is an enzyme inhibitor, a protein that regulates cell production, cell growth and cell survival.
DanyC submitted, created time 1 year 5 months (www.ij-healthgeographics.com)
"Levels of THMs in the water distribution system exhibited spatial variation that was partially due to variation in water age. researchers also observed a geographic pattern of increased risk of rectal cancer in areas with the highest levels of bromoform in the county."
Rac, membrane heterogeneity, caveolin and regulation of growth by integrins
amanda submitted, created time 1 year 6 months (www.sciencedirect.com)
"Anchorage dependence of growth blocks cell proliferation in inappropriate environments, thereby inhibiting cancer cell invasion and metastasis. Inhibition of growth regulatory pathways, including Rac, Erk and PtdIns 3-kinase in non-adherent cells mediates this effect. Here, we review recent work showing that integrin-mediated adhesion controls Rac binding to membranes. Rac binding sites can be found within cholesterol-enriched membrane domains, which are internalized when cells are deprived of adhesion
Reversing cancer cells to normal cells
Dolly submitted, created time 1 year 6 months (www.eurekalert.org)
Scientists discovered that aggressive melanoma cells (but not normal skin cells nor less aggressive melanoma cells) contain specific proteins similar to those found in embryonic stem cells. This groundbreaking work led to the first molecular classification of malignant melanoma and may help to explain how, by becoming more like unspecialized stem cells, the aggressive melanoma cell gained enhanced abilities to migrate, invade and metastasize while virtually undetected by the immune system.
Impaired expression of NER gene network in sporadic solid tumors
athena submitted, created time 1 year 6 months (nar.oxfordjournals.org)
"Nucleotide repair genes are not generally altered in sporadic solid tumors. However, point mutations are found scattered throughout the genome of cancer cells indicating that the repair pathways are dysfunctional. To address this point, in this work we focus on the expression pathways rather than in the DNA structure of repair genes related to either genome stability or essential metabolic functions."
Knocking out survival protein could aid leukemia treatment
badboy submitted, created time 1 year 6 months (www.biologynews.net)
"An effective way to fight leukemia might be to knock out a specific protein that protects cancer cells from dying, a new study shows. "
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