Articles with the keyword: 
jerry submitted, created time 1 month 6 days (sciencenow.sciencemag.org)
A new study in lab mice suggests that cells may break off from a tumor even before they become cancerous, seeding the body with cells that evade detection and lie dormant for years before turning into tumors of their own. 
UCLA researchers locate and image prostate cancer as it spreads to lymph nodes
kavin submitted, created time 2 months 3 weeks (newsroom.ucla.edu)
Using an engineered common cold virus, UCLA researchers delivered a genetic payload to prostate cancer cells that allowed them, using Positron Emission Tomography (PET), to locate the diseased cells as they spread to the lymph nodes, the first place prostate cancer goes before invading other organs.
The tiny cancer metastases in the pelvic lymph nodes are very difficult to find using conventional imaging tools such as CT scanning
New Weapon for Attacking Tumor Invasion and Metastasis
kavin submitted, created time 3 months 1 week (www.mphtimes.com)
A team led by Dr. Ji-Kun Li has determined that AMD3100, originally developed in acquired immune deficiency syndrome treatment, could markedly inhibit spreading of colorectal cancer cells by blocking a new pair of ligands and its unique receptor. This effect differs from the usual inhibition by a conventional chemotherapic agent that is more specific to cancer cells with high metastatic potential.
In vitro, AMD3100 has shown a significantly inhibitory effect on invasion and migration in colorectal cancer cell line. This effect can be further enhanced at higher concentration
Original CIN: reviewing roles for APC in chromosome instability
kavin submitted, created time 3 months 3 weeks (www.jcb.org)
You may have seen the bumper sticker "Eve was framed." Thousands of years of being blamed for original sin and still many wonder, where's the evidence? Today, the tumor suppressor adenomatous polyposis coli (APC) may have the same complaint about accusations of a different type of CIN, chromosome instability. A series of recent papers, including three in this journal, propose that loss of APC function plays an important role in the CIN seen in many colon cancer cells. However, a closer look reveals a complex story that raises more questions than answers.
Tumor Cell Metabolism: Cancer's Achilles' Heel
jerry submitted, created time 3 months 3 weeks (www.sciencedirect.com)
In this paper, scientists review the peculiarities of tumor cell metabolism that might be taken advantage of for cancer treatment. Specifically, they discuss the alterations in signal transduction pathways and/or enzymatic machineries that account for metabolic reprogramming of transformed cells.
Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase Activity
jerry submitted, created time 4 months 1 week (www.cancercell.org)
Expression of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase associated with cell proliferation and survival, is overactive in many tumors of epithelial origin. Blockade of the kinase activity of EGFR has been used for cancer therapy; however, by itself, it does not seem to reach maximum therapeutic efficacy. We report here that in human cancer cells, the function of kinase-independent EGFR is to prevent autophagic cell death by maintaining intracellular glucose level through interaction and stabilization of the sodium/glucose cotransporter 1 (SGLT1).
Tumor cells share oncogenic receptors
sea-maid submitted, created time 4 months 3 weeks (www.jcb.org)
Mutant receptors made in one tumor cell can be passed to tumor cells lacking them.
In this study, the authors found that glioma cells expressing EGFRvIII transferred this errant receptor to nonexpressing cells via microvesicles--small plasma membrane buds. The microvesicles were produced in abundance by the mutant expressing cells and were widely taken up by receptor-negative cells
Sue Wu submitted, created time 7 months 2 weeks (discovermagazine.com)
A "deep" itch can signal that something's really wrong. This well-written anecdote shows one woman coming in for a an itch in her lower back that turned out to have an ominous cause.
480 Genes That Control Human Cell Division Identified
Eric wu submitted, created time 8 months 4 weeks (www.sciencedaily.com)
A team of U.S., Israeli and German scientists used computational biology techniques to discover 480 genes that play a role in human cell division and to identify more than 100 of those genes that have an abnormal pattern of activation in cancer cells.
Nanoparticles Enable Surgical Strikes against Cancer
jane2007 submitted, created time 10 months 1 week (www.sciam.com)
In a bid to progress beyond the shotgun approach to fighting cancer—blasting malignant cells with toxic chemicals or radiation, which kills surrounding healthy cells in the process—researchers at the Harvard-MIT Division of Health Sciences and Technology (HST) are using nanotechnology to develop seek-and-destroy models to zero in on and dismantle tumors without damaging nearby normal tissue.
MIT whitecoats discover super-charged cancer cells
wugongliang submitted, created time 1 year 4 weeks (www.theregister.co.uk)
Scientists at MIT report a breakthrough in growing so called cancer stem cells that could aid research into the disease.The researchers have found a way to grow large quantities of cells that initiate tumours. These are not normally available in large quantities, so the discovery could be a real boon to those who study them.
Cells 'react' to GSM signals claims research
wugongliang submitted, created time 1 year 4 weeks (www.theregister.co.uk)
New research claims that cells can react to a GSM-like signal in as little as ten minutes - though if whether this could causes cancer remains open to interpretation.
New use for a cell toxin found to inhibit survival proteins in cancer cells
bianjie submitted, created time 1 year 2 months (www.eurekalert.org)
A chemically-modified version of a mitochondrial toxin long used to control species of invasive fish in lakes has been found to selectively inhibit two "survival proteins in cancer cells.
Tiny tweezers and yeast help St. Jude show how cancer drug works
bianjie submitted, created time 1 year 2 months (www.eurekalert.org)
The annoying bulges of an over-wound telephone cord that shorten its reach and limit a caller's motion help to explain why drugs called camptothecins are so effective in killing cancer cells, according to investigators at St. Jude Children's Research Hospital and Delft University of Technology.
Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells
Reviver submitted, created time 1 year 2 months (www.jcb.org)
"The idea that conversion of glucose to ATP is an attractive target for cancer therapy has been supported in part by the observation that glucose deprivation induces apoptosis in rodent cells transduced with the proto-oncogene MYC, but not in the parental line. Here, they found that depletion of glucose killed normal human cells irrespective of induced MYC activity and by a mechanism different from apoptosis. However, depletion of glutamine, another major nutrient consumed by cancer cells, induced apoptosis depending on MYC activity
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