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8

Biogen, Genentech to codevelop cancer drug

piggy submitted, created time 2 weeks 6 days (finance.yahoo.com)

CAMBRIDGE, Mass. (AP) -- Biogen Idec Inc. said Thursday it will pay Genentech Inc. $31.5 million upfront under a deal to co-develop a potential cancer treatment.

The companies will develop GA101, now in early-to-midstage studies as a possible treatment for non-Hodgkins lymphoma and chronic lymphocytic leukemia. Both conditions are blood cancers.

8

Novartis' profit drops 69%; 550 job cuts planned

sea-maid submitted, created time 1 month 1 day (www.fdanews.com)

Swiss drug giant Novartis said Monday that its third-quarter profit dropped 69%, as expenses to buy a stake in eye-care specialist Alcon, higher taxes and last year's gains from selling its Gerber and medical-nutrition business offset growing sales of its cancer and heart drugs.

9

Genentech Set Back by Cancer-Drug Study

jerry submitted, created time 1 month 2 weeks (online.wsj.com)

Genentech Inc. and OSI Pharmaceuticals Inc. said a late-stage trial showed that adding the cancer medicine Avastin to the drug Tarceva didn't prolong the lives of patients with advanced lung cancer.

6

Gloucester Reports Positive Results From Phase II Study of Lymphoma Drug

kavin submitted, created time 5 months 3 days (www.redorbit.com)

Gloucester Pharmaceuticals has reported positive data from a Phase II trial of romidepsin, a novel, cyclic peptide, pan-HDAC inhibitor under investigation for hematologic malignancies.

The study conducted by the US National Cancer Institute is a seven-arm, phase II, open-label trial of romidepsin in patients with cutaneous T-cell lymphoma (CTCL) and peripheral T-cell lymphoma (PTCL). The study enrolled 71 CTCL patients in three arms of the study that received romidepsin. Patients received 14mg/m2 of romidepsin infused on days one, eight and 15 every 28 days

11

Fireflies' glow gene helps researchers evaluate cancer drugs

Sue Wu submitted, created time 5 months 2 weeks (www.topnews.in)

Researchers at UT Southwestern Medical Center have used a gene, which produces a flash in fireflies, to track the effectiveness of anti-cancer drugs.

In a first of its kind effort, researchers have now shown that a technique called bioluminescence imaging (BLI) can be used to determine the effectiveness of cancer drugs that obstruct the blood supply to a tumor.

8

Cancer Drug -- Promising New Design Found

DanyC submitted, created time 8 months 2 weeks (health.usnews.com)

A drug that targets a protein interaction involved in many types of cancer has been created by University of Michigan researchers.
PS:
Many traditional cancer drugs also activate p53, but they do so by causing DNA damage.

5

Danger coming with hope: Amgen's Anemia Drugs Ailing

DanyC submitted, created time 8 months 3 weeks (www.forbes.com)

There is a $10 billion market for drugs to treat the anemia that occurs after kidney dialysis and cancer chemotherapy. Well, a new study said Amgen and Johnson & Johnson's anti-anemia treatments raise the risk of death via blood clots, and worries coming, that these medicines actually harm patients when overused have caused doctors to limit prescriptions.

12

Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease

Reviewer submitted, created time 1 year 3 months (www.discover8.com)

The article published in Eukaryote cell at 2005 by Dr. Gentry MS, and Dr. Li Y et al is a milestone, in this study they firstly described a novel in vivo immunofluorescence assay based on the heterotrimer dependent localization of green fluorescent protein (GFP)-PP2A subunits. The new data show for the first time the differential effects of methylation, and likely phosphorylation, on these two PP2A B-type subunit families

11

Kids often get unapproved drugs for sleep problems

DanyC submitted, created time 1 year 3 months (www.reutershealth.com)

A new study shows, doctors commonly prescribe drugs to children and teens with sleep difficulties that are not approved for use by patients in these age groups.

5

Can the right foods reduce cancer treatment costs?

DanyC submitted, created time 1 year 4 months (www.reutershealth.com)

U.S. researchers said on Monday, taking advantage of the power of food to boost the effectiveness of drugs could sharply lower the cost of cancer treatments.

5

gene test not needed if cancer drug given in low doses

bioman submitted, created time 1 year 5 months (www.eurekalert.org)

When the cancer drug irinotecan is given in low doses for multiple days, it eliminates the need to delay treatment to perform costly genetic testing that determines if the patient is at risk for serious treatment side effects, such as neutropenia. Neutropenia is an abnormal reduction in the numbers of immune cells, called neutrophils; the disorder leaves individuals more vulnerable to infections

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