Articles with the keyword: 


Genetic study undermines case for CRP as cause of vascular disease
piggy submitted, created time 3 weeks 1 day (www.theheart.org)
Copenhagen, Denmark- Is C-reactive protein (CRP) a promoter of cardiovascular disease or simply a marker of increased cardiovascular risk? Probably the latter, according to the latest study to address the question, in which four gene variants tied to sharply increased CRP levels were shown not to be associated with an elevated CV-event risk 


Combined impact of lifestyle factors on mortality: prospective cohort study in U.S. women
sea-maid submitted, created time 2 months 3 days (www.bmj.com)
Objective: To evaluate the impact of combinations of lifestyle factors on mortality in middle aged women.
Design Prospective: cohort study.
Setting: Nurses’ health study, United States.
Participants: 77,782 women aged thirty-four to fifty-nine years and free from cardiovascular disease and cancer in 1980 


Heartbeat patterns could keep wireless implants secure
sea-maid submitted, created time 2 months 2 weeks (technology.newscientist.com)
If future medical implants are to communicate safely, they need to be hacker resistant – a person's pulse could provide the key. 


jane2007 submitted, created time 7 months 2 weeks (www.nature.com)
A recent spate of worrying clinical-trial data has researchers questioning drugs approved on the basis of how they affect biomarkers rather than clinical endpoints. Heidi Ledford looks at surrogate markers. 
Triumphs and tribulations for RNA interference
jane2007 submitted, created time 7 months 3 weeks (www.nature.com)
Two studies highlight promise and problems for gene silencing technique. Researchers could offer a new way by microRNA interference to treat conditions from cancer to cardiovascular disease. But another study shows that the effects of RNAi on genes involved in a severe form of blindness called age-related macular degeneration (AMD). In this case RNAi-causing drugs have already gone into trials. It isn't that the drugs don't work; it's that they work no matter what siRNA sequence is used. This brings the current understanding of the mechanism of RNA interference into question. 


Discovery in rat hearts could lead to tailored transplants
Darkfrog submitted, created time 10 months 1 week (www.nature.com)
A few years back, I described induced pluripotent stem cells as "the holy grail." This is what stem cell researchers were looking for: a way to produce rejection-proof cells specifically tailored to the patient's system. However, stem cells still can't be grown into organs all by themselves -- we can make liver tissue but we can't make a liver. They need a frame upon which to grow.
And some guys from the University of Minnesota just found out how to get one. 


Hydrogen sulfide mediates the vasoactivity of garlic
william submitted, created time 1 year 4 weeks (www.pnas.org)
The consumption of garlic is inversely correlated with the progression of cardiovascular disease, although the responsible mechanisms remain unclear. Here we show that human RBCs convert garlic-derived organic polysulfides into hydrogen sulfide (H2S), an endogenous cardioprotective vascular cell signaling molecule. 


Cruciferous Indole-3-Carbinol Inhibits Apolipoprotein B Secretion in HepG2 Cells
kattam submitted, created time 1 year 2 months (jn.nutrition.org)
It contains important information pertaining to the class of compounds called indoles and their potential role in the treatment of cardiovascular disease which is the leading cause of mortality in the western world today.It provide a mechanistic explanation to how this compound might mediate their effects to reduce the levels of bad cholesterol in blood. 


It's not too late to change -- lowering cardiac risk later in life
BIOBOSS submitted, created time 1 year 4 months (www.eurekalert.org)
Can adopting a healthier lifestyle later in life help -- or is it too late? In a study published in the July 2007 issue of the American Journal of Medicine, researchers from the Medical University of South Carolina, Charleston found that people 45 to 64 years of age who added healthy lifestyle behaviors could substantially reduce their risk for cardiovascular disease and reduce their death rate. 


Women's mortality rates for cardiovascular disease differ widely among hospitals
BIOBOSS submitted, created time 1 year 4 months (www.eurekalert.org)
Women treated for cardiovascular disease at the nation's best- performing hospitals have a 39 percent lower risk-adjusted mortality rate when compared with women at the nation's poorest-performing hospitals, according to the fourth annual HealthGrades Women's Health Outcomes in US Hospitals study, released today. The study also found that, for women, the largest quality gaps between the best-performing and poorest-performing hospitals were in heart failure and interventional cardiology procedures. 


Intakes of Calcium and Vitamin D and Breast Cancer Risk in Women
captainclaw submitted, created time 1 year 5 months (archinte.ama-assn.org)
"The findings from this study suggest that higher intakes of calcium and vitamin D may be associated with a lower risk of developing premenopausal breast cancer. The likely apparent protection in premenopausal women may be more pronounced for more aggressive breast tumors." 


Effect of Aerobic Exercise Training on Serum Levels of High-Density Lipoprotein Cholesterol
Reviver submitted, created time 1 year 5 months (archinte.ama-assn.org)
"Regular aerobic exercise modestly increases HDL-C level. There appears to exist a minimum exercise volume for a significant increase in HDL-C level. Exercise duration per session was the most important element of an exercise prescription. Exercise was more effective in subjects with initially high total cholesterol levels or low body mass index." 


May Contribute To Cardiovascular Disease
Dolly submitted, created time 1 year 5 months (www.sciencedaily.com)
A new dissertation shows that Chlamydia pneumoniae can contribute to cardiovascular disease. Half of the population of Swedish twenty-year-olds are carriers of the bacterium Chlamydia pneumoniae, an ubiquitous pathogen previously known to cause acute respiratory disease. It now appears that this bacterium also contributes to cardiovascular disease, the single greatest killer disease in the western world. 


medal submitted, created time 1 year 5 months (hyper.ahajournals.org)
"Inappropriate left ventricular mass predicts the risk of cardiovascular (CV) events, independent of risk factors, either in the presence or in the absence of traditionally defined LV hypertrophy. The relation between changes in appropriateness of LVM during antihypertensive treatment and subsequent prognosis was evaluated in 436 prospectively identified uncomplicated hypertensive subjects, with a baseline and follow-up standard clinical evaluation, laboratory examinations, and echocardiogram (last examination: 6±3 years apart), followed for additional 4.5±2.5 years 


Migraine and Risk of Cardiovascular Disease in Men
julie submitted, created time 1 year 6 months (archinte.ama-assn.org)
"In this large prospective cohort of apparently healthy men, migraine was associated with increased risk of major CVD, which was driven by increased risk of myocardial infarction.
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