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Protein Kinase CK2: new perspectives of an old kinase

yarmoluk submitted, created time 1 month 4 weeks (www.discover8.com)

Protein Kinase CK2: new perspectives of an old kinase

Design of specific small molecules that are able to block (inhibit) function of macromolecular targets responsible for the development of certain disorder is the “classic” and most widely used approach in modern drug therapeutics, e.g., in cancer treatment

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Ukrainian company Otava develop novel casein kinase 2 (CK2) inhibitors as anticancer drugs.

yarmoluk submitted, created time 8 months 2 weeks (www.discover8.com)

Over the past few years our company, OTAVA Ltd., has designed novel, efficient at low micro molar concentrations, and selective CK2 inhibitors. To discover the new inhibitors, our researchers spanned computer-based molecular modeling with chemical synthesis of compounds which were further tested in vitro to investigate their ability to bind to and affect the activity of CK2.

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