Articles with the keyword: 
Tumor Secrets Written in Blood
piggy submitted, created time 3 days 17 hours (sciencenow.sciencemag.org)
Doctors may soon be able to use blood tests rather than invasive biopsies to figure out what type of brain tumors their patients have. The findings, which come thanks to new insights about how tumor cells communicate with their environment, may also bring physicians closer to the goal of more personalized medicine.
Cells are chatty, constantly exchanging proteins or electrical signals with their neighbors. For example, tumor cells can signal nearby blood vessels to grow in their direction, thereby facilitating tumor growth 
New nano device detects immune system cell signaling
sea-maid submitted, created time 2 months 2 weeks (esciencenews.com)
Scientists have detected previously unnoticed chemical signals that individual cells use to communicate with each other over short distances. Minding the communiques of individual cells might not be so important for studying the heart or bones, but it is absolutely crucial to studying the immune system.
DNA Damage Signals for p53 Pulses
jerry submitted, created time 5 months 4 weeks (www.sciencedirect.com)
A major challenge of systems biology is to understand how network topology affects protein dynamics in living cells. A new study show that p53 pulses are driven by pulses in the upstream signaling kinases, ATM and Chk2, and that a negative feedback mediated by the phosphatase Wip1 is essential for maintaining the uniform shape of p53 pulses.
Signaling specifically from the endosome
sea-maid submitted, created time 6 months 1 week (www.jcb.org)
In this study, it is the first time Akt signaling has been shown from the endosome. And the Akt is known to signal from the plasma membrane, but an upstream regulator of Akt called APPL1, which is known to interact directly with Akt, has been reported to reside on endosomes.
Apoptosis: Killing neutrophils the cathepsin way
davidd submitted, created time 6 months 3 weeks (www.signaling-gateway.org)
Cathepsin D directly cleaves and activates caspase-8 at the beginning of a pro-apoptotic pathway in neutrophils, showing how apoptosis can be activated in the absence of death-receptor ligation.
cytokinesis unveiled: forming the furrows
sea-maid submitted, created time 6 months 3 weeks (www.jcb.org)
This paper is about a monopolar HeLa system which is used to determine how the cytokinetic furrow is created. From the research,the author tells us that splitting mitotic cells in two is not the one-way signaling road it once seemed, based on evidence from Hu et al.
Bcl-2-Regulated Calcium Signals as Common Mediators of Both Apoptosis and Autophagy
Vincent submitted, created time 8 months 1 week (www.sciencedirect.com)
Macroautophagy is an evolutionary conserved lysosomal pathway involved in the turnover of cellular macromolecules and organelles. In spite of its essential role in tissue homeostasis, the molecular mechanisms regulating mammalian macroautophagy are poorly understood. Here, we demonstrate that a rise in the free cytosolic calcium ([Ca2+]c) is a potent inducer of macroautophagy
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
davidd submitted, created time 8 months 3 weeks (www.pnas.org)
B-RAF is the most frequent oncogenic protein kinase mutation known. Furthermore, inhibitors targeting "active" protein kinases have demonstrated significant utility in the therapeutic repertoire against cancer. The article represents the entire discovery process of a selective inhibitor , from initial identification through structural and biological studies in animal models to a promising therapeutic for testing in cancer patients bearing B-RafV600E-driven tumors.
Signaling to muscle satellite cells
sumsung submitted, created time 9 months 2 weeks (www.nature.com)
Researchers led by Rita Perlingeiro at the University of Texas Southwestern Medical School, differentiated mouse embryonic stem cells into muscle progenitor cells which restored function when infused into mice with a mouse version of Duchenne's muscular dystrophy, a wasting disease.
Clearance of apoptotic cells by phagocytes
davidd submitted, created time 9 months 3 weeks (www.nature.com)
This article is a review about clearance of apoptotic cells by phagocytes. Here, they illustrate the knowledge about the initial attraction signals, the specific mechanisms of engulfment and processing in comparison to the extensive literature on recognition mechanisms.
For Remote-Control Cells, Just Add Magnets
jane2007 submitted, created time 10 months 1 week (www.sciam.com)
A new study suggests that to meld living cells with the digital world, think of them as you would a refrigerator door—a handy place to stick magnets. I was attracted when i read first paragraph, it's a interesting breakthrough.
Researchers Use Magnetic Fields, Rather Than Drugs, to Control Cellular Signaling
Eric wu submitted, created time 10 months 1 week (www.sciencedaily.com)
Researchers at Children's Hospital Boston have developed a new "nanobiotechnology" that enables magnetic control of events at the cellular level. They describe the technology, which could lead to finely-tuned but noninvasive treatments for disease, in the January issue of Nature Nanotechnology (published online January 3).
Turning on cells with magnetic switches
jane2007 submitted, created time 10 months 3 weeks (harvardscience.harvard.edu)
Harvard scientists have figured out how to turn cells on and off using magnets, an advance with potentially broad applications as researchers around the world work to find new ways to manipulate cells and correct cellular functions that diseases send awry.
Insulin Secretion Aided By Message From Fat Cells
june submitted, created time 1 year 2 weeks (www.medicalnewstoday.com)
In a study using laboratory mice, published in the November 7, 2007 issue of Cell Metabolism, scientists at the School of Medicine report that fat cells release a protein that aids insulin secretion from pancreatic beta cells, which are the sole source of insulin. The protein is an enzyme that the pancreatic cells themselves produce in only minimal amounts. The enzyme works to enhance glucose-stimulated insulin secretion from pancreatic beta cells.
New support for stem cells as pit crew
Hecate submitted, created time 1 year 2 weeks (sciam.com)
Lab-mutated neurodeficient mice were injected with stem cells from 12-day-old mouse brains, resulting in marked improvement. In contrast to beliefs from just a few years ago, the injected cells didn't grow into new brain tissue. Like volunteers spicing up an old folks' home, they stimulated the damaged cells to behave in a more effective fashion.
Another revelation from this study (UC@Irvine) seems to be that the cells congregated in the damaged regions of the mouse brains. We're not sure what made them do it or what made them stay.
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