Articles with the keyword: 
sea-maid submitted, created time 10 months 3 weeks (www.nature.com)
Bevacizumab, brand name Avastin, is the first anti-cancer drug designed specifically to starve tumors of blood. However, phase-three clinical trials seem to show that it is no more effective than chemotherapy alone.
There was a certain amount of industry drama associated with Avastin: Earlier this year Roche bought the company that produces it, Genentech, for $95 per share, a total of around $47 billion and a whole lot of nail-biting by Genentech employees, who value their company's freestyle corporate culture and feared that a takeover by Roche would stifle it 
Pfizer ends trial early for cancer drug Sutent
piggy submitted, created time 11 months 2 weeks (finance.yahoo.com)
Pfizer Inc. said Thursday it stopped a late-stage study of the cancer drug Sutent to treat a form of advanced breast cancer but will continue examining the drug in several other mid- and late-stage trials.
The drug maker said it stopped a study that compared the results of Sutent with those of capecitabine when each was used alone in patients who had already tried standard treatments
Three-drug Chemotherapy Combination Increases Organ Preservation in Patients with Larynx Cancer
sea-maid submitted, created time 11 months 2 weeks (www.sciencedaily.com)
Patients with larynx cancer who received a three-drug combination of docetaxel, cisplatin and 5-fluorouracil (TPF) during induction chemotherapy were more likely to retain larynx function than were patients treated with cisplatin and 5-fluorouracil (PF) alone, according to data from a randomized controlled trial in the March 24 online issue of the Journal of the National Cancer Institute.
This treatment was used as an alternative to removal of the larynx
A sticky business -- how cancer cells become more gloopy as they die
piggy submitted, created time 1 year 5 days (www.eurekalert.org)
The viscosity, or gloopiness, of different parts of cancer cells increases dramatically when they are blasted with light-activated cancer drugs, according to new images that provide fundamental insights into how cancer cells die, published in Nature Chemistry today (15 March).
The images reveal the physical changes that occur inside cancer cells whilst they are dying as a result of photodynamic therapy (PDT). This cancer treatment uses light to activate a drug that creates a short-lived and toxic type of oxygen, called singlet oxygen, which kills cancerous cells
Twin Nanoparticle Shown Effective at Targeting and Killing Breast Cancer Cells
sea-maid submitted, created time 1 year 1 week (www.sciencedaily.com)
Breast cancer patients face many horrors, including those that arise when fighting the cancer itself. Medications given during chemotherapy can have wicked side effects, including vomiting, dizziness, anemia and hair loss. These side effects occur because medications released into the body target healthy cells as well as tumor cells.
Researchers from Brown University have developed a twin nanoparticle that specifically targets only the Her-2 cancer cell, delivering tiny doses of cisplasin directly to the malignant cell.
Brain Tumor Drug May Help Spur Cancer's Return
sea-maid submitted, created time 1 year 2 weeks (health.yahoo.com)
Temozolomide, a standard treatment for brain cancer, may boost the aggressiveness of surviving cancer cells, making tumor recurrence more likely, a new study suggests.
Certain stem-cell-like cancer cells, called gliomas, can survive chemotherapy if they have access to protein ABCG2, which expels anti-cancer drugs from the cell. These gliomas are then free to regenerate once chemotherapy is done.
Scientists Develop Crystal Ball for Personalized Cancer Treatment
piggy submitted, created time 1 year 1 month (www.sciencedaily.com)
For many cancer patients, chemotherapy can be worse than cancer itself. A patient may respond to one drug but not another -- or the tumor may mutate and stop responding to the drug -- resulting in months of wasted time, ineffective treatment and toxic side effects.
Now UCLA scientists have tested a non-invasive approach that may one day allow doctors to evaluate a tumor's response to a drug before prescribing therapy, enabling physicians to quickly pinpoint the most effective treatment and personalize it to the patient's unique biochemistry
How Cancer Cells Survive a Chemotherapy Drug
piggy submitted, created time 1 year 1 month (wis-wander.weizmann.ac.il)
What separates the few cancer cells that survive chemotherapy--leaving the door open to recurrence-–from those that don’t? Weizmann Institute scientists developed an original method for imaging and analyzing many thousands of living cells to reveal exactly how a chemotherapy drug affects each one.
For research student Ariel Cohen, together with Naama Geva-Zatorsky and Eran Eden in the lab of Prof. Uri Alon of the Institute’s Molecular Cell Biology Department, the question posed an interesting challenge
How chemotherapy drugs block blood vessel growth, slow cancer spread
sea-maid submitted, created time 1 year 1 month (www.eurekalert.org)
Researchers at the Johns Hopkins University School of Medicine have discovered how a whole class of commonly used chemotherapy drugs can block cancer growth. Their findings, reported online this week at the Proceedings of the National Academy of Sciences Early Edition, suggest that a subgroup of cancer patients might particularly benefit from these drugs.
New Drug May Work Better Against Chemo Side Effects
sea-maid submitted, created time 1 year 2 months (health.yahoo.com)
A drug that better prevents the nausea and vomiting that commonly follows chemotherapy treatment for cancer may be on the horizon, Japanese researchers report.
HWI scientist unravels structure of key breast cancer target enzyme
piggy submitted, created time 1 year 2 months (www.eurekalert.org)
The molecular details of aromatase, the key enzyme required for the body to make estrogen, are no longer a mystery thanks to the structural biology work done by the Ghosh lab at the Hauptman-Woodward Medical Research Institute (HWI) in Buffalo, New York. Dr. Debashis Ghosh's solution of the three-dimensional structure of aromatase is the first time that scientists have been able to visualize the mechanism of synthesizing estrogen
Scientists can now differentiate between healthy cells and cancer cells
piggy submitted, created time 1 year 2 months (www.eurekalert.org)
One of the current handicaps of cancer treatments is the difficulty of aiming these treatments at destroying malignant cells without killing healthy cells in the process. But a new study by McMaster University researchers has provided insight into how scientists might develop therapies and drugs that more carefully target cancer, while sparing normal healthy cells
Mick Bhatia, scientific director of the McMaster Stem Cell and Cancer Research Institute in the Michael G
Team finds breast cancer gene linked to metastasis
piggy submitted, created time 1 year 2 months (www.princeton.edu)
A team of researchers at Princeton University and The Cancer Institute of New Jersey has identified a long-sought gene that is fatefully switched on in thirty to forty percent of all breast cancer patients, spreading the disease, resisting traditional chemotherapies and eventually leading to death.
The gene, called "Metadherin" or MTDH, is located in a small region of human chromosome 8 and appears to be crucial to cancer's spread or metastasis because it helps tumor cells stick tightly to blood vessels in distant organs
Nanotubes Sniff Out Cancer Agents in Living Cells
piggy submitted, created time 1 year 3 months (www.sciencedaily.com)
MIT engineers have developed carbon nanotubes into sensors for cancer drugs and other DNA-damaging agents inside living cells.
The sensors, made of carbon nanotubes wrapped in DNA, can detect chemotherapy drugs such as cisplatin as well as environmental toxins and free radicals that damage DNA.
"We've made a sensor that can be placed in living cells, healthy or malignant, and actually detect several different classes of molecules that damage DNA," said Michael Strano, associate professor of chemical engineering and senior author of a paper on the work appearing in the Dec
Study suggests some breast cancer patients facing radiation after a mastectomy may be over-treated
sea-maid submitted, created time 1 year 6 months (esciencenews.com)
A new study suggests standard radiation therapy for some breast cancer patients may not be medically required and may, therefore, be causing unnecessary serious side effects such as lymphedema and pulmonary problems. The research conducted at Fox Chase Cancer Center involved women who got a mastectomy, but whose lymph nodes were negative. "When a woman has a tumor greater than five centimeters and negative lymph nodes, a mastectomy followed by radiation is recommended," said Penny Anderson, M.D., attending physician in the radiation oncology department at Fox Chase
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