Articles with the keyword: 
Novartis could cut drug development by a year
piggy submitted, created time 19 hours 48 minutes (www.reuters.com)
A new way of conducting clinical trials could allow Novartis AG to cut the time needed to develop some drugs by a year, the Swiss drug maker's designated development head said on Wednesday.
The new approach, which uses disease models to predict measurable markers and responses, could apply in areas like oncology and genetic diseases and allow mid-stage trials to be shortened or even, in some cases, omitted completely. 
Ark floats gene therapy's boat, for now
sea-maid submitted, created time 3 weeks 6 days (www.nature.com)
In August, gene therapy's turbulent ride through the clinical rapids took a new twist as Ark Therapeutics released positive top-line results from a phase 3 trial of its adenoviral gene therapy Cerepro (sitimagene ceradenovec) for malignant brain tumors. Although the news boosted the London-based firm's shares, the course to market authorization and registration remains strewn with uncertainty—as Introgen, of Austin, Texas, found, to its cost, when the U.S
Government HIV vaccine doesn't make it out the gate
Darkfrog submitted, created time 4 months 3 days (www.nytimes.com)
Plans for a large-scale clinical trial of an HIV vaccine developed by the U.S. government were cancelled this week. The researchers fear jumping into human trials too soon, without knowing more about how their vaccine will affect the volunteers. Here is a quote:
"The trial canceled Thursday was supposed to have started enrolling 8,500 volunteers last October to receive the PAVE [Partnership for AIDS Vaccine Evaluation] vaccine, developed by the infectious diseases agency
Stopping clinical trials early
sea-maid submitted, created time 5 months 2 weeks (www.bmj.com)
Should we be worried about an apparent rise in the number of clinical trials now being stopped early because the results are so good? Margaret McCartney asks how convincing should results be before trials are halted - and what the implications are for patients.
Compulsive gamblers always down on their luck
kavin submitted, created time 6 months 4 weeks (www.eurekalert.org)
According to a study published today in the open access journal Clinical Practice and Epidemiology in Mental Health, gambling addicts don't learn from their mistakes. And it predisposes a person to the development of impulsive or compulsive behaviour, leading to pathological gambling.
FDA to vet embryonic stem cells’ safety
jane2007 submitted, created time 7 months 1 week (www.nature.com)
Investors, biotech companies and other stem-cell stakeholders are meeting in Gaithersburg, Maryland, this week for FDA’s first public hearing on the safety of therapies that use human embryonic stem cells.
jane2007 submitted, created time 7 months 2 weeks (www.nature.com)
A recent spate of worrying clinical-trial data has researchers questioning drugs approved on the basis of how they affect biomarkers rather than clinical endpoints. Heidi Ledford looks at surrogate markers.
Trial of Cholesterol Drug Gets House Scrutiny
jane2007 submitted, created time 11 months 1 week (www.nytimes.com)
A Congressional committee is investigating Merck and Schering-Plough for their handling of a critical clinical trial of Zetia, their blockbuster cholesterol-lowering drug.
jane2007 submitted, created time 11 months 3 weeks (www.nature.com)
A clinical trial of gene therapy in which a woman died this summer is due to recommence.
The article give us a explanation why the trial restart and the views of people. I think it good for us understand the gene theraphy.
jane2007 submitted, created time 1 year 1 week (www.nature.com)
An HIV vaccine made by Merck that failed in clinical trials may have increased the susceptibility of some trial participants to the AIDS virus, researchers reported last week. The findings have left scientists grappling with the problem of how to handle future trials of vaccines that use similar strategies to stimulate an immune response.
I read an article about the failure of Merck, this article is about it too, but you can get an different view.
Stress, Pain, and Paris Hilton
wugongliang submitted, created time 1 year 2 weeks (sciencenow.sciencemag.org)
Neuroscientists have found that a cardboard cutout of the ubiquitous Hilton Hotel heiress has a painkilling effect on mice. But don't expect clinical trials to begin anytime soon: Paris works only for males, and it may be only because she stresses them out.
Clinical decision modeling system
biomedguru submitted, created time 1 year 2 weeks (www.biomedcentral.com)
This paper describes the world's first software designed specifically to facilitate integrative translational research. Researchers using the software will be able to plan effective integrative clinical trials that examine the utility of specific clinical workflows that integrate biomarkers, imaging, clinical and demographic data.
The software is available online here:
http://bioinformatics.pitt.edu/software/cdms/
Medicare will not cover stents for neck arteries
Darkfrog submitted, created time 1 year 6 months (www.nytimes.com)
Heart stents made the news recently, but this article discusses stents that are placed in neck arteries to prevent stroke. The issue isn't whether or not they work but who will pay for them.
Dr. Barry T. Katzen, director of the Baptist Cardiac and Vascular Institute in Miami, says that this will actually help research: By linking their willingness to pay to the efficacy of clinical trials, he says, they will influence doctors to be more stringent with those trials.
He sure sounds as though he's making the best of it. Thoughts?
Texas legislature blocks mandatory HPV vaccination
Darkfrog submitted, created time 1 year 6 months (www.nytimes.com)
The Texas legislature has overruled Governor Perry's decree that all sixth-grade (about eleven years old) girls in Texas must be vaccinated with the HPV vaccine. This ruling does not in any way ban vaccination; it only says that the governor may not require it. Also, the ruling will only be in force for four years. Unless it is renewed, the governor of Texas may revisit the idea of mandatory HPV vaccinations in 2011
julie submitted, created time 1 year 7 months (circ.ahajournals.org)
"Fasting plasma glucose is an independent predictor of hospitalization for CHF in high-risk subjects. These data provide theoretical support for potential direct beneficial effects of glucose lowering in reducing the risk of CHF and suggests the need for specific studies targeted at this issue. "
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