Articles with the keyword: 
Calcium May Only Protect Against Colorectal Cancer in Presence of Magnesium
sea-maid submitted, created time 3 days 17 hours (www.sciencedaily.com)
High magnesium intake has been associated with low risk of colorectal cancer. Americans have similar average magnesium intake as East Asian populations. If that were all that were involved, observers might expect both groups to have similar risk for colorectal cancer 
Race-specific cancer mutation found
jane2007 submitted, created time 7 months 3 weeks (www.nature.com)
Researchers have identified a specific genetic mutation raises the risk of colon cancer in Caucasians by 10% but not in Japanese.
Cancer awareness: Colon growths might be a long way
DanyC submitted, created time 8 months 2 weeks (www.sciencenews.org)
A new study suggests that these out-of-the-blue cancers may arise from nonpolyp growths. Such tissues are less conspicuous than polyps, but the new data suggest that they occur with some regularity and might be more dangerous than polyps. While polyps outnumbered nonpolyp growths, lab analyses showed that the nonpolyp kind was at least five times as likely to be cancerous.
Diabetes Increases Colorectal Cancer Risk for Women
jane2007 submitted, created time 11 months 1 week (www.abcnews.go.com)
Women with diabetes already have to manage a complex diagnosis and treatment protocol. Now they may have another disconcerting diagnosis: colorectal cancer.
Analysis of breast and colon cancer genes finds many areas of differences between tumors
kitty submitted, created time 1 year 1 month (www.eurekalert.org)
Researchers from University Hospitals Ireland Cancer Center and Case Western Reserve University School of Medicine are part of a new national study that has analyzed more than 18,000 genes, including 5,000 previously unmapped genes, from breast and colorectal tumors. The study shows a great number of genetic differences between breast and colon cancer tumors, leading the researchers to conclude that new drugs must be developed that can hit these newly identified genetic targets in a manner specific to each different individual's tumor.
Inside job: new radioactive agents for colon cancer work inside cells
zibba submitted, created time 1 year 1 month (www.eurekalert.org)
Johns Hopkins scientists have developed a potentially novel way to fight colorectal cancer using tiny molecules to deliver potent barrages of radiation inside cancer cells, unlike current treatments that bind to the surface of cells and attack from the outside and cause unwanted side effects.
A search for biomarkers for early detection of colorectal cancer
william submitted, created time 1 year 1 month (www.eurekalert.org)
Using two-dimensional gel electrophoresis, 27 differentially expressed proteins were identified in colorectal adenoma, compared with individual-matched normal mucosa and cancer tissue. In those proteins, the differential expression of two novel proteins, mimecan and thioredoxin domain-containing protein 5 (TXNDC5), were validated by Western-blot. This study clearly demonstrated that absence of mimecan and up-regulation of TXNDC5 were involved in the early development of colorectal cancer.
jiangyun submitted, created time 1 year 2 months (carcin.oxfordjournals.org)
Our data provide new insight into the mechanism by which n-3 PUFA suppress tumorigenesis through dampening of inflammation and NF-B activity. These results support a protective role of n-3 PUFA supplementation in the prevention of colorectal cancer.
Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors
jiangyun submitted, created time 1 year 2 months (carcin.oxfordjournals.org)
Our results demonstrate that DKKs are frequent targets of epigenetic silencing in gastrointestinal tumors, and that loss of DKKs may facilitate tumorigenesis through ß-catenin/TCF independent mechanisms
Aspirin, COX-2, and the Risk of Colorectal Cancer
jiangyun submitted, created time 1 year 2 months (content.nejm.org)
Chan et al. (May 24 issue)evaluated the influence of aspirin on the risk of colorectal cancer according to the expression of cyclooxygenase-2 (COX-2) in the resected tumors and found a significantly reduced risk of colorectal cancers with overexpression of COX-2. We offer an alternative interpretation of the data.
Researchers probe risks, benefits of folic acid fortification
bianjie submitted, created time 1 year 4 months (www.eurekalert.org)
Researchers at Tufts University report a temporal relationship between nationwide folic acid fortification and an increase in rates of colorectal cancer. Their analysis and resulting hypothesis adds to ongoing debate and suggests further research on total population effects of fortification.
Study identifies a common genetic risk factor for colorectal and prostate cancer
bianjie submitted, created time 1 year 4 months (www.eurekalert.org)
A study led by researchers at the Keck School of Medicine of the University of Southern California has found that one of seven genetic risk factors previously identified as increasing the probability of developing prostate cancer also increases the probability of developing colorectal cancer.
Improving Colorectal Cancer Treatment
gh0706 submitted, created time 1 year 4 months (www.sciencedaily.com)
Researchers have provided new information about a protein responsible for colorectal cancer and the target of a potential drug against this cancer. Claus Lindbjerg Andersen, Torben Falck Orntoft, and colleagues discovered that clusterin , which has been linked to the development of tumor cells and resistance to cancer therapy, is not expressed in normal cells, while in 25 percent of colorectal tumors, the cancer cells contained clusterin. They also showed that the protein is actually made by the cancer cells themselves
New Study Suggests Folic Acid Does Not Prevent Colorectal Tumours
angelfish submitted, created time 1 year 5 months (www.medicalnewstoday.com)
Dr Bernard F Cole of Dartmouth Medical School, Hanover, New Hampshire and colleagues conducted a nine-centre trial in the US and Canada between 1994 and 2004 involving 1,021 patients of average age 57 who had recently had at least one colorectal adenoma removed within three months of enrollment but with no history of colorectal cancer.Adenomas or polyps are benign growths that form singly or in clumps and may become malignant over time.The patients were randomly assigned to receive either folic acid supplement (1 mg per day) or placebo and underwent colonoscopy about 3 years afterwards
Aspirin and the Risk of Colorectal Cancer in Relation to the Expression of COX-2
penguin submitted, created time 1 year 5 months (content.nejm.org)
Regular use of aspirin reduces the risk of a colorectal neoplasm, but the mechanism by which aspirin affects carcinogenesis in the colon is not well understood. We estimated cyclooxygenase-2 (COX-2) expression by immunohistochemical assay of sections from paraffin-embedded colorectal-cancer specimens from two large cohorts of participants who provided data on aspirin use from a questionnaire every 2 years. We applied Cox regression to a competing-risks analysis to compare the effects of aspirin use on the relative risk of colorectal cancer in relation to the expression of COX-2 in the tumor
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