RhoA/Rho-Kinase Contribute to the Pathogenesis of Diabetic Renal Disease

jerry submitted, created time 5 months 3 weeks (diabetes.diabetesjournals.org)

This article tells us that high glucose activates RhoA/Rho-kinase in MCs, leading to downstream AP-1 activation and fibronectin induction. Inhibition of this pathway in vivo prevents the pathologic changes of diabetic nephropathy, supporting a potential role for inhibitors of RhoA/Rho in the treatment of diabetic renal disease.

4 comments | Blog It | Email It | Keywords: renal disease AP-1 kidneys diabetes RhoA Rho diabetic renal disease Rho kinase