Caffeine extends yeast lifespan by targeting TORC1

kavin submitted, created time 4 months 2 weeks (www.ncbi.nlm.nih.gov)

Dietary nutrient limitation (dietary restriction) is known to increase lifespan in a variety of organisms. Although the molecular events that couple dietary restriction to increased lifespan are not clear, studies of the model eukaryote Saccharomyces cerevisiae have implicated several nutrient-sensitive kinases, including the target of rapamycin complex 1 (TORC1), Sch9, protein kinase A (PKA) and Rim15. We have recently demonstrated that TORC1 activates Sch9 by direct phosphorylation. We now show that Sch9 inhibits Rim15 also by direct phosphorylation

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Red wine ingredient wards off effects of age on heart, bones, eyes and muscle

kavin submitted, created time 4 months 3 weeks (esciencenews.com)

Large doses of a red wine ingredient can ward off many of the vagaries of aging in mice who begin taking it at midlife, according to a new report published online on July 3rd in Cell Metabolism, a Cell Press publication. Those health improvements of the chemical known as resveratrol—including cardiovascular benefits, greater motor coordination, reduced cataracts and better bone density—come without necessarily extending the animals' lifespan. Sinclair and de Cabo's team further show evidence that resveratrol mimics the beneficial effects of eating fewer calories

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Food Restriction Increases Dopamine Receptor Levels in Obese Rats

Siegfried submitted, created time 1 year 4 weeks (www.bnl.gov)

A brain-imaging study of genetically obese rats conducted at the U.S. Department of Energy's Brookhaven National Laboratory provides more evidence that dopamine - a brain chemical associated with reward, pleasure, movement, and motivation - plays a role in obesity. The scientists found that genetically obese rats had lower levels of dopamine D2 receptors than lean rats. They also demonstrated that restricting food intake can increase the number of D2 receptors, partially attenuating a normal decline associated with aging.

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