Articles with the keyword:
12

Resistance to drugs responsible for half of deaths from infections

sea-maid submitted, created time 5 months 3 weeks (www.bmj.com)

Multidrug resistant bacteria are responsible for about half of the 37,000 deaths a year in the 27 member states of the European Union that are caused by infections associated with health care, show the preliminary results of research from the European Centre for Disease Prevention and Control in Stockholm.

8

Drug-Resistant Flu Virus on the Rise

Sue Wu submitted, created time 10 months 17 hours (www.time.com)

This winter's most common flu strain is showing resistance to the frontline anti-flu treatment, new data shows.

5

Tuberculosis exposure feared on India-to-U.S. flight

Eric wu submitted, created time 10 months 3 weeks (www.reuters.com)

U.S. health officials are trying to track down 44 people who sat near a woman infected with a hard-to-treat form of tuberculosis aboard an airliner from India to determine whether they have been infected, authorities said on Friday.

5

Identification of H2N3 influenza A viruses from swine in the United States

davidd submitted, created time 10 months 3 weeks (www.pnas.org)

In this report, they isolate and characterize genetically similar avian/swine virus reassortant H2N3 influenza A viruses isolated from diseased swine from two farms in the United States. The H2N3 viruses were able to cause disease in experimentally infected swine and mice without prior adaptation. In addition, the swine H2N3 virus was infectious and highly transmissible in swine and ferrets. Taken together, these findings suggest that the H2N3 virus has undergone some adaptation to the mammalian host and that their spread should be very closely monitored.

5

The evolution of a killer---tuberculosis

jane2007 submitted, created time 1 year 2 days (www.nature.com)

The work suggests that if better tuberculosis surveillance programmes had been in place during the past decade in developing countries, antibiotic treatments could have been better tailored to patients, and the emergence of extensively drug-resistant strains of tuberculosis (XDR-TB) could have been delayed.
This article narrates the history and the current status of the killer--- tuberculosis. I think the difficulty or the mission is in the text too.

10

Superbug Knocks Out Patient's Defense

yangjane submitted, created time 1 year 2 weeks (sciencenow.sciencemag.org)

Methicillin-resistant Staphylococcus aureus (MRSA infect immunocompromised and sick people in hospitals. Researchers have discovered how these bugs, which some see as a major public health threat, do their damage. They discovered that CA-MRSA strains produce peptides called phenol-soluble modulins (PSMs) in much greater quantities than do hospital strains. When the researchers knocked out the genes for four of these peptides, the so-called α-type PSMs, CA-MRSA bacteria became much milder in mice: Skin infections were less severe, and bacteremia was less often fatal.

6

Drug-resistant bacteria found to trick immune system

Eric wu submitted, created time 1 year 2 weeks (www.reuters.com)

Drug-resistant bacteria called methicillin-resistant Staphylococcus aureus, or MRSA, may be able to first lure and then destroy immune system cells when they are the most vulnerable, researchers said on Sunday.
(The news has given us a warning of not abusing Drug-resistant bacteria. These drugs would destroy our immune system and the result is very harmfull to all of us.So,I recommend this article. )

11

Fusing nanotechnology with cell biology to battle the ‘superbug’

jane2007 submitted, created time 1 year 2 weeks (www.topnews.in)

Nanotechnology scientists at the University of Idaho start ed a new project with a view to integrating nanonmaterials research with cell biology and bioscience research. He said that his team was trying to harness nanowires and other nanomaterials to hijack the methods bacteria use for toxin delivery, and to deliver drug therapies specifically to infected cells.

9

Lilly gets FDA nod on new osteoporosis drug use

abc01 submitted, created time 1 year 2 months (www.reutershealth.com)

Eli Lilly & Co said Friday that it had won approval to market its blockbuster osteoporosis drug to post-menopausal women who are at high risk for invasive breast cancer.

5

Other highlights from the July 10 JNCI

bianjie submitted, created time 1 year 4 months (www.eurekalert.org)

Also in the July 10 JNCI are studies on a "nanobubble" drug delivery method, a gene that may promote chemotherapy drug resistance, and an association between vitamin D and reduced colon cancer risk.

5

New way to detect forms of HIV found

gh0706 submitted, created time 1 year 5 months (www.sciencedaily.com)

U.S. medical researchers have developed a new method of screening for drug-resistant forms of the human immunodeficiency virus. Researchers at the University of Pennsylvania School of Medicine have developed a drug resistance screening method of analyzing multiple HIV variants. They said that the new technique could open opportunities for improved drug-resistance screening around the world.

5

Support for chromosomal theory of cancer found in cancers' development of drug resistance

BIOBOSS submitted, created time 1 year 5 months (www.eurekalert.org)

Most cancer researchers are convinced that cancer results from a handful of genetic mutations that kick a cell into uncontrolled growth. UC Berkeley genetics researcher Peter Duesberg disagrees, and finds support for his "chromosomal" theory of cancer in the development of drug resistance by many cancers. While his theory implies their is no magic bullet against cancer, it does provide ways to detect cancer at an early stage.

5

RNA Interference against MDR1 but not MRP1 Reverses Drug Resistance in Human Small-Cell Lung Cancer Cells

MedUnion submitted, created time 1 year 5 months (www.mupnet.com)

AIM: Human small-cell lung carcinoma (SCLC) cells can express two drug efflux pumps, MDR1 and MRP1, possibly involved in drug resistance. The aim of this study was to investigate the ex vivo significance of these pumps.
METHODS: We transfected small interfering RNA (siRNA) directed against the mRNAs of these two genes into drug-sensitive (H69) and drug-resistant (H69VP) SCLC cells and tested down-regulation of gene expression, cytotoxicity, and drug accumulation by calcein efflux.
RESULTS: After 24 h, RT-PCR showed down-regulation of the targeted mRNAs

5

Drug resistance doesn't always come from drugs

newsdigg submitted, created time 1 year 5 months (www.nature.com)

Influenza 'accidentally' hit on drug resistance through natural evolution. Influenza resistance to a powerful group of antiviral drugs, the adamantane family, has worryingly jumped from 2% to 90% in recent years around the world. This dramatic shift was initially attributed to drug selection pressure: throwing adamantane drugs at viruses should select for influenza strains that evade those drugs. But a new study hints that this isn't the cause of the increased resistance; instead it seems viruses developed the resistance on their own accord.

5

454 sequencing identifies HIV drug resistance at early stage

BIOBOSS submitted, created time 1 year 5 months (www.eurekalert.org)

454 Life Sciences, a member of the Roche group, and a Yale School of Medicine researcher today announced that they have used the company's Genome Sequencer system to identify previously undetectable rare drug resistant HIV variants in samples from an earlier performed clinical trial.

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