Articles with the keyword: 
Derailed endocytosis: an emerging feature of cancer
sea-maid submitted, created time 1 month 16 hours (www.nature.com)
Once engaged by soluble or matrix-anchored ligands, cell surface proteins are commonly sorted to lysosomal degradation through several endocytic pathways. Defective vesicular trafficking of growth factor receptors, as well as unbalanced recycling of integrin- and cadherin-based adhesion complexes, has emerged in the past five years as a multifaceted hallmark of malignant cells 
New mutant collection examines six thousand genes. Next big thing in drug discovery?
jerry submitted, created time 2 months 4 weeks (stke.sciencemag.org)
A major challenge in drug discovery is to identify the cellular targets responsible for the pharmacological activity of drug candidates. In the yeast Saccharomyces cerevisiae, a heterozygous diploid mutant collection of approximately six thousand strains, in each of which one copy of a single gene is deleted, is commercially available. With this collection, it is possible to evaluate the role of each gene product in the response of cells to a drug
A Lipidic-Sponge Phase Screen for Membrane Protein Crystallization
jerry submitted, created time 4 months 2 weeks (www.structure.org)
A major current deficit in structural biology is the lack of high-resolution structures of eukaryotic membrane proteins, many of which are key drug targets for the treatment of disease. Numerous eukaryotic membrane proteins require specific lipids for their stability and activity, and efforts to crystallize and solve the structures of membrane proteins that do not address the issue of lipids frequently end in failure rather than success. To help address this problem, they have developed a sparse matrix crystallization screen consisting of 48 lipidic-sponge phase conditions
New Gene for Alzheimer's Discovered
lily1984 submitted, created time 5 months 6 days (www.bloomberg.com)
Scientists have discovered a gene that raises the risk of late-onset Alzheimer's disease by as much as 77 percent and provides scientists with a second genetic target for developing new treatments for the disorder.
One copy of the gene, called calcium homeostasis modulator 1, or CALHM1, increases the likelihood of late-onset Alzheimer's by 44 percent, while two copies boost the risk 77 percent. About a quarter of the population has one copy, said study author Philippe Marambaud from the Albert Einstein College of Medicine in New York. The research was published in the journal Cell
From sequence to function: using RNAi to elucidate mechanisms of human disease
davidd submitted, created time 7 months 2 weeks (www.nature.com)
RNA interference (RNAi) has emerged as one of the most powerful tools for functionally characterizing large sets of genomic data. The capabilities of RNAi place it at the forefront of high-throughput screens, which are able to span the human genome in search of novel targets. The article assess the prospective applications of high-throughput screens, the data they are capable of generating, and the potential for this technique to further our understanding of human disease.
Mutation May Explain Deadly Form of Leukemia
Sue Wu submitted, created time 7 months 2 weeks (sciencenow.sciencemag.org)
A new study indicates that mutations in the Ikaros gene play a role in triggering acute lymphoblastic leukemia (ALL), an aggressive, treatment-resistant form of cancer.
Gene hunters uncover networks behind disease
jane2007 submitted, created time 8 months 2 weeks (www.nature.com)
Researchers have used a new technique to identify networks of genes linked to obesity in both mice and humans. The new approach looks at changes in expression of already-known genes, and finds networks of genes associated with disease, rather than single switches.
Enzyme Structure Reveals New Drug Targets for Cancer and Other Diseases
Eric wu submitted, created time 9 months 1 week (www.sciencedaily.com)
If the genome is the parts list of the human cell, certain proteins are the production managers, activating and deactivating genes as needed. Scientists funded by the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health, now have a clearer understanding of how a key protein controls gene activity and how mutations in the protein may cause disease. The work could provide new avenues to design drugs aimed at cancer, diabetes, HIV, and heart disease.
Sifting the Genome for Clues to Cancer
sumsung submitted, created time 9 months 4 weeks (sciencenow.sciencemag.org)
Biologists have hunted for weak spots in cancer cells for years, hoping to find clues to the disease that can be exploited. That should get easier thanks to a mass-screening technique reported in the 1 February issue of Science that may provide a cost-effective and powerful way to pick out new drug targets against cancer.
"Normal" genes key to cancer growth
jane2007 submitted, created time 10 months 19 hours (www.nature.com)
Geneticists have identified genes that are normally present and that seem to be key to the growth and survival of specific cancers. The finding, from a functional-genomics screen of human cells, could offer new drug targets for blitzing tumors.
New Cholesterol Genes found are potentially attractive drug targets
DanyC submitted, created time 10 months 2 weeks (www.webmd.com)
Two of the newly identified genes only affect HDL cholesterol, one only affects LDL cholesterol, three only affect triglycerides, and one affects LDL cholesterol and triglycerides. it may be possible to tailor cholesterol and triglyceride treatments to patients
Proteins That Could Be Used to Halt HIV Are Identified
Sue Wu submitted, created time 10 months 2 weeks (www.washingtonpost.com)
A research team announced yesterday that it has identified about 270 human proteins that the AIDS virus apparently needs to infect a person, instantly providing researchers with dozens of new strategies for blocking or aborting HIV infection.
jane2007 submitted, created time 10 months 2 weeks (www.nature.com)
This article open a door for us to cure HIV. Researchers have now identified over 250 of the human proteins that are needed by HIV to help it spread throughout the body, providing a treasure trove of potential HIV drug targets. In other words, the proteins needed by HIV will become the killer helper of HIV drugs.
Proteins That AIDS Virus Preys On
sumsung submitted, created time 10 months 2 weeks (www.time.com)
The AIDS virus has to hijack human proteins to do its damage, but scientists until now have known only a few dozen of its targets. On Thursday, Harvard researchers unveiled a surprisingly longer list, an important first step in the hunt for new drugs.
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