Articles with the keyword: 
FDA to vet embryonic stem cells’ safety
jane2007 submitted, created time 7 months 1 week (www.nature.com)
Investors, biotech companies and other stem-cell stakeholders are meeting in Gaithersburg, Maryland, this week for FDA’s first public hearing on the safety of therapies that use human embryonic stem cells. 
The impact of chromatin modifiers on the timing of locus replication in mouse ES cells
jiangyun submitted, created time 1 year 2 months (genomebiology.com)
The time of locus replication during S-phase is tightly regulated and correlates with chromatin state. Embryonic stem (ES) cells have an unusual chromatin profile where many developmental regulator genes, that are not yet expressed, are marked by both active and repressive histone modifications. This poised or bivalent state is also characterized by locus replication in early S-phase in ES cells, while replication timing is delayed in cells with restricted developmental options.
PGD may harm embryonic viability, stem-cell harvesting
Darkfrog submitted, created time 1 year 4 months (www.nytimes.com)
A study presented at the European Society of Human Reproduction and Embryology shows that embryos grown from post-PGD blastocysts have a lower chance of growing successfully into a baby.
The focus of the article is on older women seeking children, but it also has ramifications for stem cells, which we learned some months ago can be grown from the daughter cells of PGD blastomeres.
Stem cell genes may provide medicine's dream ticket
Reviver submitted, created time 1 year 5 months (www.newscientist.com)
"GENE therapy meets stem cells. That is the wave of the future, if the recent annual meeting of the American Society of Gene Therapy in Seattle is any guide. There was a palpable buzz around efforts to correct diseases by targeting therapeutic genes to stem cells already resident in the body.Stem cells have obvious appeal as targets for gene therapy, in which genes are inserted into an individual's cells in order to treat a disease
Skin makes embryonic stem cells
captainclaw submitted, created time 1 year 5 months (www.abc.net.au)
Researchers have taken ordinary skin cells from a mouse and reprogrammed them to look and act like embryonic stem cells in a long-promised experiment that provides an alternative way to get these valued and controversial cells.
A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells
captainclaw submitted, created time 1 year 5 months (www.genome.org)
"Embryonic stem (ES) cells are pluripotent cell lines with the capacity of self-renewal and the ability to differentiate into specific cell types. Researchers performed the first genome-wide analysis of the mouse ES cell transcriptome using ~250,000 gene trap sequence tags deposited in public databases. They unveiled >8000 novel transcripts, mostly non-coding, and >1000 novel alternative and often tissue-specific exons of known genes. Experimental verification of the expression of these genes and exons by RT-PCR yielded a 70% validation rate
Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells
deirdre submitted, created time 1 year 5 months (www.nature.com)
The pluripotency of embryonic stem (ES) cells is thought to be maintained by a few key transcription factors, including Oct3/4 and Sox2. The function of Oct3/4 in ES cells has been extensively characterized, but that of Sox2 has yet to be determined. Sox2 can act synergistically with Oct3/4 in vitro to activate Oct–Sox enhancers, which regulate the expression of pluripotent stem cell-specific genes, including Nanog, Oct3/4 and Sox2 itself.
Heart repair may soon be within reach
bigben submitted, created time 1 year 6 months (www.jem.org)
Researchers at the Mayo Clinic, Rochester, MN (Behfar et al., J Exp Med. 2007 Feb 19) found a simple way to isolate a large quantity of cardiac progenitors or cardiopoietic cells, to prevent tumor growth when stem cells are delivered in vivo, to escape from host immunity and ,finally, to repair injured heart. “Recruited cardiopoietic cells delivered in infarcted hearts generated cardiomyocytes that proliferated into scar tissue, integrating with host myocardium for tumor-free repair
Gene plays key role in embryonic, adult stem cells
medal submitted, created time 1 year 6 months (www.reuters.com)
"One gene directs both embryonic and adult stem cells to perform the self-renewal function that is crucial in their potential broad use in medical treatments, researchers said on Thursday."
athena submitted, created time 1 year 7 months (www.sciencedirect.com)
"Over the past few years, human embryonic stem cells (hESCs) have gained popularity as a potentially ideal cell candidate for tissue regeneration. In particular, hESCs are capable of cardiac lineage-specific differentiation and confer improvement of cardiac function following transplantation into animal models. Although such data are encouraging, there remain significant hurdles before safe and successful translation of hESC-based treatment into clinical therapy, including the ability to assess cells following transplant
newsdigg submitted, created time 1 year 7 months (bloodjournal.hematologylibrary.org)
Recent studies have demonstrated that cell populations intended for therapeutic purposes that are cultured in heterologous animal products can acquire xenoantigens, potentially limiting their utility. In investigations of the immune response to murine embryonic stem (ES) cells, we found that a strong antibody response was generated after the second infusion. Both polyclonal and monoclonal antibody responses, derived from immunized mice, were found to be specific for bovine apolipoprotein B-100 which binds to abundant low density lipoprotein receptor on the cell surface and is internalized
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