Articles with the keyword: 
Newly discovered molecular switch helps decide cell type in early embryo development
sea-maid submitted, created time 3 weeks 5 days (www.eurekalert.org)
Researchers have discovered a central molecular switch in fruit fly embryos that opens new avenues for studying the causes of birth defects and cancer in humans. Writing about their study in the Aug. 12 Developmental Cell, scientists at Cincinnati Children's Hospital Medical Center determined the switch to be a main tuning mechanism for instructing cells whether to form sensory nerves or blood cells in different parts of the body. 
They're calling it "biological alchemy": induced stem cells proliferate
sea-maid submitted, created time 1 month 4 weeks (www.newscientist.com)
CALL it biological alchemy: specialist pancreatic cells that secrete digestive enzymes have been converted directly into insulin-producing beta cells. Meanwhile, epithelial cells from the back of the eye have been coaxed into becoming a versatile, new type of stem cell.
Both advances, reported last week in Philadelphia, Pennsylvania, at the annual meeting of the International Society for Stem Cell Research (ISSCR), may take us closer to a "regenerative" approach to repairing damaged tissue
Nuclear Pore Composition Regulates Neural Stem/Progenitor Cell Differentiation in the Mouse Embryos
jerry submitted, created time 2 months 2 days (www.developmentalcell.com)
Serving as the primary conduit for communication between the nucleus and the cytoplasm, nuclear pore complexes (NPCs) impact nearly every cellular process. The extent to which NPC composition varies and the functional significance of such variation in mammalian development has not been investigated. Here they report that a null allele of mouse nucleoporin Nup133, a structural subunit of the NPC, disrupts neural differentiation. They found that expression of Nup133 was cell type and developmental stage restricted, with prominent expression in dividing progenitors
Hybrid Embryo Ban Is Defeated in Britain
Sue Wu submitted, created time 3 months 2 weeks (www.timesonline.co.uk)
The House of Commons has defeated a bill that would have banned the creation of so-called hybrid embryos—part human and part animal—for medical research. That means scientists who obtain proper licenses will be allowed to create hybrid embryos by transferring DNA from human cells into animal eggs that have had most of their genetic information removed. The embryos would then be grown in a laboratory and their stem cells would be harvested for up to 14 days, after which they would be destroyed
First GM human embryo is created!
Sue Wu submitted, created time 3 months 3 weeks (www.timesonline.co.uk)
Scientists have created what is believed to be the first genetically modified (GM) human embryo.
A team from Cornell University in New York produced the GM embryo to study how early cells and diseases develop. It was destroyed after five days
jerry submitted, created time 3 months 4 weeks (www.developmentalcell.com)
Surprisingly, sensitive-to-resistant transition happened in post-stage-12 embryos when they are irradiated.
The magic key of this is in the irradiation-responsive enhancer regions of the proapoptotic genes. It becomes enriched for trimethylated H3K27/H3K9 and forms a heterochromatin-like structure during the sensitive-to-resistant transition.
Further review of "three-parent" embryo technique
Darkfrog submitted, created time 6 months 4 weeks (www.nature.com)
This is another discussion of the mother-father-mitochondiadonor embryo that I mentioned the other day. It is significantly more revealing. It seems that the mitochondrial transfer involved moving nuclear DNA from the diseased embryo to the healthy one instead of into an ovum from another source.
It also discusses their methods. It seems that the exchange was performed in embryos that had failed in other experiments. The ten successes came from many failures. The specific success to failure ratio is not given.
"Three-parent" technique: mitochondrial replacement could prevent muscular dystrophy and epilepsy
Darkfrog submitted, created time 7 months 22 hours (news.nationalgeographic.com)
It sounds more impressive than it is -- they've replaced the mitochondria, not portions of the somatic DNA.
A team at Newcastle University has constructed ten embryos, presumably viable, that hold DNA from one man and two women. Doctors see this technique as a means by which parents carrying genetic diseases may have their own (mostly) genetic offspring without going all the way to sperm donors, egg donors or surrogates
Novel genes 'notch' glucose into place
jane2007 submitted, created time 7 months 1 week (www.bcm.edu)
A novel gene called rumi regulates Notch signaling by adding a glucose molecule to the part of the Notch protein that extends outside a cell. It is also a key gene to specify neurons in the peripheral and central nervous system. When embryos lack a functional Notch protein, they have far too many neurons. The same phenomenon can be observed in rumi mutant embryos.
Human Embryos Cloned From Skin Cells
Eric wu submitted, created time 7 months 2 weeks (sciencenow.sciencemag.org)
A new breakthrough on stem-cell research!
A major breakthrough occurred last year when scientists figured out how to turn skin cells into ES-like cells. But they still want to be able to do cloning, otherwise known as somatic cell nuclear transfer (SCNT), because embryonic cells are the "gold standard" for pluripotent cells--cells that can become any cell type in the body. In addition, scientists want to learn more about how an oocyte can reprogram a mature cell back into an ES cell.
Human embryos cloned from adult cells
Charles submitted, created time 7 months 2 weeks (www.nature.com)
A California company has brought human cloning research to a new level with efficient production of cloned human blastocysts — an early stage of embryos.
jane2007 submitted, created time 7 months 3 weeks (www.nature.com)
Researchers have found that embryos of C. elegans unlucky enough to be missing one particular gene, called zeel-1, die early in development if their male parent delivered a metaphorical bomb into their embryotic life in the form of a compound produced from an incompatible version of another gene, peel-1, in his sperm.
Hold the Embryos: Genes turn skin into stem cells
yangjane submitted, created time 9 months 2 weeks (www.sciencenews.org)
In an advance that could solve many of the ethical and technical issues involved in stem cell research, two groups of scientists have independently converted human skin cells directly into stem cells without creating or destroying embryos.
Should Fertilized Eggs Have Rights?
Eric wu submitted, created time 9 months 2 weeks (www.time.com)
If Colorado for Equal Rights for Human Life and other anti-abortion groups can wrangle 76,000 signatures in the next six months, theirs could be the first state in the nation to vote on whether a fertilized egg should legally be considered a person. Despite resistance from abortion-rights groups, the Colorado Supreme Court on November 13 approved the ballot measure — 40 years after Colorado became the first state to relax abortion laws — giving a boost to a conservative political movement that has worked doggedly for decades to overturn Roe v. Wade
Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions
sumsung submitted, created time 1 year 1 month (www.pnas.org)
Using a combination of techniques we developed, we infected zebrafish embryos using pseudotyped retroviruses and mapped the genomic locations of the proviral integrations in the F1 offspring of the infected fish. From F1 fish, we obtained 2,045 sequences representing 933 unique retroviral integrations.
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