Leptin and Amylin Agonism: a Hope for Diet-induced Obesity

davidd submitted, created time 1 year 9 months (www.pnas.org)

Body weight is regulated by complex neurohormonal interactions between endocrine signals of long-term adiposity (e.g., leptin, a hypothalamic signal) and short-term satiety (e.g., amylin, a hindbrain signal). Leptin has been placed too much hope on weight loss. It became a failure for weight loss in non-leptin-deficient, diet-induced obese (DIO) rodents and humans. Today, we have some good news for for the obese. This study reports that concurrent peripheral administration of amylin and leptin elicits synergistic, fat-specific weight loss in leptin-resistant, diet-induced obese rats.

1 comment | Blog It | Email It | Keywords: endocrinology food appetite hypothalamus Agonism Amylin Leptin obesity

Gene Expression Analysis of Endometrium Reveals Progesterone Resistance and Candidate Susceptibility Genes in Women with Endometriosis

annatto submitted, created time 2 years 7 months (endo.endojournals.org)

"Paralleled gene expression analysis of endometrial specimens obtained during the early secretory phase demonstrated a signature of enhanced cellular survival and persistent expression of genes involved in DNA synthesis and cellular mitosis in the setting of endometriosis. ...more in Endocrinology "

Submit comment | Blog It | Email It | Keywords: Endocrinology IL-2 gene DNA synthesis

A decisive step toward a cure for insulin dependent diabetes

bianjie submitted, created time 2 years 8 months (www.muhc.ca)

Today, a diagnosis of type I diabetes means a life sentence of medical follow-up. The latest study published in the journal Nature by Dr. Constantin Polychronakos, director of the Pediatric Endocrinology Department at the McGill University Health Center, in collaboration with Dr. Hakon Hakonarson, director of the Center for Applied Genomics of the Children's Hospital of Philadelphia, provides hope that this situation will evolve in the long term toward a cure for this disease.

Submit comment | Blog It | Email It | Keywords: Type I diabetes Endocrinology

Enjoying Anger Encourages People Learning

crackpot submitted, created time 2 years 11 months (www.newscientist.com)

Testosterone levels are known to be higher in socially dominant individuals.Angry faces stimulating because they could signal a challenge to their dominance. Alternatively, they may indicate a foe who has already been defeated or otherwise upset, thus reinforcing the viewer's dominant status.
The researchers found that volunteers with high testosterone levels learned the keystroke pattern more quickly if they saw an angry face than otherwise

1 comment | Blog It | Email It | Keywords: Testosterone levels Endocrinology Neurological Scientist