IgG glycan hydrolysis by a bacterial enzyme as a therapy against autoimmune conditions

davidd submitted, created time 8 months 1 week (www.pnas.org)

EndoS from Streptococcus pyogenes efficiently hydrolyzes the functionally important and conserved N-linked glycan of IgG in human blood. Repeated i.v. administration of EndoS in rabbits completely hydrolyzes the glycans of the whole IgG pool, despite the generation of anti-EndoS antibodies. EndoS administration had no apparent effects on the health of the animals

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