High consumption of coffee or tea every day appears to protect male smokers against at least one type of stroke

kavin submitted, created time 4 months 4 weeks (www.medscape.com)

This large, prospective, observational study showed that Finnish smokers who consumed eight or more cups of coffee per day had a 23% lowered risk for cerebral infarction, whereas those who drank two or more cups of black tea daily had a 21% lowered risk for this type of stroke vs those who drank little or none of these beverages. The associations were independent of risk factors such as a history of coronary heart disease.

Their report is published in the June 2008 issue of Stroke

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Trimetazidine improves endothelial dysfunction in chronic heart failure: an antioxidant effect

amanda submitted, created time 1 year 6 months (eurheartj.oxfordjournals.org)

"TMZ improves the ED-relaxation in patients with ischaemic cardiomyopathy. The antioxidant properties of TMZ may play a role. "

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Genetic deletion of p66Shc adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress

cappuccion submitted, created time 1 year 8 months (www.pnas.org)

Increased production of reactive oxygen species (ROS) and loss of endothelial NO bioavailability are key features of vascular disease in diabetes mellitus. The p66Shc adaptor protein controls cellular responses to oxidative stress. Mice lacking p66Shc (p66Shc–/–) have increased resistance to ROS and prolonged life span. The present work was designed to investigate hyperglycemia-associated changes in endothelial function in a model of insulin-dependent diabetes mellitus p66Shc–/– mouse. p66Shc–/– and wild-type (WT) mice were injected with citrate buffer (control) or made diabetic by an i.p

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