Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase Activity

jerry submitted, created time 6 months 5 days (www.cancercell.org)

Expression of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase associated with cell proliferation and survival, is overactive in many tumors of epithelial origin. Blockade of the kinase activity of EGFR has been used for cancer therapy; however, by itself, it does not seem to reach maximum therapeutic efficacy. We report here that in human cancer cells, the function of kinase-independent EGFR is to prevent autophagic cell death by maintaining intracellular glucose level through interaction and stabilization of the sodium/glucose cotransporter 1 (SGLT1).

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A Sweet New Role for EGFR ...in Cancer!

Genetic Variation Doubles Risk of Liver Cancer

Sue Wu submitted, created time 10 months 4 weeks (health.usnews.com)

WEDNESDAY, Jan. 2 (HealthDay News) -- A single change in the epidermal growth factor (EFG) gene may double the risk of developing liver tumors, especially among people with cirrhosis, new research suggests.

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Roles of Epidermal Growth Factor Family in the Regulation of Postnatal Somatic Growth

fiona submitted, created time 1 year 6 months (edrv.endojournals.org)

"Ligands of the epidermal growth factor receptor (EGF-R), known to be important for supporting tissue development particularly in the gut and brain, have also been implicated in regulating postnatal somatic growth."

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Clinical Application of Epidermal Growth Factor Receptor–Tyrosine Kinase Inhibitors against Non-Small Cell Lung Cancer

MedUnion submitted, created time 1 year 7 months (www.mupnet.com)

Single-agent epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib or erlotinib, have a response rate of 20-30% against NSCLC in East Asians who have received prior chemotherapy, while the response rate was only ~10% in unselected white patients. In addition to East Asian populations who have a higher response rate, the response rates are higher in women, persons with adenocarcinoma, and those who have never smoked. These findings can be partly explained by the higher incidence of EGFR mutations in these groups of patients with NSCLC

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The Hypoxia-Inducible Factor 2 alpha N-Terminal and C-Terminal Transactivation Domains Cooperate To Promote Renal Tumorigenesis In Vivo

DanyC submitted, created time 1 year 8 months (mcb.asm.org)

“Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor, consisting of an alpha subunit and a beta subunit, that controls cellular responses to hypoxia. HIF contains two transcriptional activation domains called the N-terminal transactivation domain (NTAD) and the C-terminal transactivation domain (CTAD). HIF alpha is destabilized by prolyl hydroxylation catalyzed by EglN family members. In addition, CTAD function is inhibited by asparagine hydroxylation catalyzed by FIH1. Both hydroxylation reactions are linked to oxygen availability

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Glucocorticoid and Growth Factor Synergism Requirement for Notch4 Chromatin Domain Activation

DanyC submitted, created time 1 year 8 months (mcb.asm.org)

“The signal-dependent transcription factor activator protein 1 (AP-1) activates Notch4 transcription in endothelial cells, but other factors/signals that regulate Notch4 are largely unknown. Scientists demonstrate that, unlike the established transrepression mechanism in which the glucocorticoid receptor (GR) antagonizes AP-1, AP-1 and GR synergistically activated Notch4 transcription in endothelial cells

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Epidermal growth factor receptor mutations in lung cancer

amanda submitted, created time 1 year 8 months (www.nature.com)

Understanding the genetic heterogeneity of epithelial tumours and devising strategies to circumvent their rapid acquisition of resistance to targeted kinase inhibitors are essential to the successful use of targeted therapies in common epithelial cancers.

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