Articles with the keyword: 


Psychiatry has a new theory of genes and behavior: Genetic tug-of-war determines brain development
Darkfrog submitted, created time 2 weeks 5 days (www.nytimes.com)
In what the New York Times calls a "creative" interpretation of recent findings about the nature of DNA, two scientists, biologist Bernard Crespi of Fraser University and sociologist Christopher Badcock of the London school of economics, have come up with a new idea of how mental disorders develop and how genes fit into the whole thing:
"Their idea is, in broad outline, straightforward. Dr. Crespi and Dr. Badcock propose that an evolutionary tug of war between genes from the father’s sperm and the mother’s egg can, in effect, tip brain development in one of two ways 


Personal genomes: The case of the missing heritability
sea-maid submitted, created time 3 weeks 1 day (www.nature.com)
When scientists opened up the human genome, they expected to find the genetic components of common traits and diseases. But they were nowhere to be seen. Brendan Maher shines a light on six places where the missing loot could be stashed away. 


Gene regulation makes humans human
sea-maid submitted, created time 2 months 3 weeks (www.sciencenews.org)
The regulation of genes, rather than genes alone, may have been crucial to primate evolution. Nearly identical stretches of DNA in chimps and humans trigger different effects in the developing body, triggered by non-coding regions. 


Study shows more genes are controlled by biological clocks
sea-maid submitted, created time 3 months 15 hours (esciencenews.com)
The tick-tock of your biological clock may have just gotten a little louder. Researchers at the University of Georgia report that the number of genes under control of in living things than suspected only a few years ago. The biological clock in a much-studied model organism is dramatically higher than previously reported. The new study implies that the clock may be much more important. 


Lifetime lessons of DNA change
sea-maid submitted, created time 5 months 5 days (www.nature.com)
Study of how genome is chemically altered as we age could help us understand disease. 
Heterochromatin kills kinetochores
jerry submitted, created time 6 months 2 weeks (www.developmentalcell.com)
This research tells us that a dynamic balance between centromeric chromatin and heterochromatin is essential for vertebrate kinetochore activity. They used an artificial chromosome (HAC) to manipulate the epigenetic state of chromatin within an active kinetochore. When they changed the state of the chromosome, they lost the kinetochore proteins. 


jerry submitted, created time 6 months 3 weeks (www.cancercell.org)
This paper adds a new dimension to the relationship between the ubiquitin-proteasome system and epigenetic regulation of transcription.
These studies elucidated a critical means of regulation for REST, with implications for neuronal stem cell differentiation and the dual roles of this protein as a tumor suppressor and oncogene. These findings and their significance are discussed herein. 


Cytosine methylation profiling of cancer cell lines
davidd submitted, created time 8 months 5 days (www.pnas.org)
DNA methylation changes in human cancer are complex and vary between the different types of cancer. Capturing this epigenetic variability in an atlas of DNA-methylation changes will be beneficial for basic research as well as translational medicine. Hypothesis-free approaches that interrogate methylation patterns genome-wide have already generated promising results. 
Epigenetic Regulation of EpCAM in Tumor Invasion and Metastasis
MedUnion submitted, created time 9 months 2 weeks (www.mupnet.com)
Metastatic progression is the cause of most cancer decease. Many cell surface adhesion molecules are known to be present or re-expressed following gene promoter CpG island hypomethylation in the early stage of growing tumors, but absent or reduced by gene promoter CpG hypermethylation in metastasized carcinomas. Recent studies have revealed that an adhesion receptor, epithelial cell adhesion molecule (EpCAM), mediates cell-cell interaction and is involved in tumor invasion and metastasis. EpCAM expression was associated with promoter CpG methylation in lung adenocarcinoma 


UD leads $5.3-million research project on rice epigenetics
bianjie submitted, created time 1 year 2 months (www.udel.edu)
Using a novel "deep sequencing" technology that can in one fell swoop decode 50 million sequences representing well over a billion bases of DNA, a research team led by University of Delaware scientists is working to unmask where, why and how certain genes are switched on or off in rice -- a crop vital to the world's food supply. 


Molecular studies of major depressive disorder: the epigenetic perspective
penguin submitted, created time 1 year 6 months (www.nature.com)
Major depressive disorder (MDD) is a common and highly heterogeneous psychiatric disorder encompassing a spectrum of symptoms involving deficits to a range of cognitive, psychomotor and emotional processes. As is the norm for aetiological studies into the majority of psychiatric phenotypes, particular focus has fallen on the interplay between genetic and environmental factors. There are, however, several epidemiological, clinical and molecular peculiarities associated with MDD that are hard to explain using traditional gene- and environment-based approaches 


DNA demethylation in the Arabidopsis genome
Cindy submitted, created time 1 year 7 months (www.pnas.org)
Cytosine DNA methylation is considered to be a stable epigenetic mark, but active demethylation has been observed in both plants and animals. In Arabidopsis thaliana, DNA glycosylases of the DEMETER (DME) family remove methylcytosines from DNA. Demethylation by DME is necessary for genomic imprinting, and demethylation by a related protein, REPRESSOR OF SILENCING1, prevents gene silencing in a transgenic background. However, the extent and function of demethylation by DEMETER-LIKE (DML) proteins in WT plants is not known 
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