Articles with the keyword: 
FDA: Epilepsy drug may be risky for Asians
piggy submitted, created time 4 days 14 hours (www.fda.gov)
FDA is investigating new preliminary data regarding a potential increased risk of serious skin reactions including Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) from phenytoin therapy in Asian patients positive for a particular human leukocyte antigen (HLA) allele, HLA-B*1502. This allele occurs almost exclusively in patients with ancestry across broad areas of Asia, including Han Chinese, Filipinos, Malaysians, South Asian Indians, and Thais 
Epilepsy drug may be risky for Asians
sea-maid submitted, created time 4 days 15 hours (news.yahoo.com)
Treatment with certain epilepsy drugs may expose some Asian patients to serious skin reactions, federal health officials warned Monday.
The Food and Drug Administration said it is investigating whether medications like Dilantin, Phenytek and Cerebyx, which are used to control epileptic seizures, can lead to severe skin blisters and bleeding for some Asian patients.
Patients who test positive for a gene known as HLA-B1502 appear to be at increased risk of developing the skin problems, preliminary data indicate
How to stop a new type of heart attack
sea-maid submitted, created time 3 months 1 week (technology.newscientist.com)
PACEMAKERS are supposed to protect people from heart attacks. But to do that they have to provide digital as well as biological security.
Earlier this year, a team led by William Maisel at Harvard Medical School demonstrated how a commercial radio transmitter could be used to modify wireless communications from a pacemaker (New Scientist, 22 March, p 23). Doctors normally use these signals to monitor and adjust the implanted device, but a malicious hacker could reprogram the pacemaker to give its wearer damaging shocks, or run down its batteries
High-Fat Diet Found to Fight Seizures in Kids
kavin submitted, created time 3 months 2 weeks (www.usnews.com)
A diet high in fat—extremely high in fat, that is—has just been shown in a clinical trial to cut seizure frequency in children with severe, drug-resistant epilepsy. It's not a cure, and it's not an easy treatment to stomach, but it works, British researchers reported Friday in the journal Lancet Neurology.
Dr. Atkins himself might have gagged on the therapeutic regimen, which is called the ketogenic diet. It's so fatty that carbohydrates and protein combined aren't permitted to account for more than twenty-five percent of total calories
Suicidal actions linked with epilepsy drugs
kavin submitted, created time 5 months 1 week (today.reuters.co.uk)
WASHINGTON (Reuters) - Epilepsy drugs are associated with a higher risk of suicidal thoughts and behavior, U.S. drug reviewers said in an analysis that was released on Wednesday and mirrored earlier findings.
"The effect appears consistent among the group of 11 drugs" that were reviewed, according to a summary from statistical reviewers at the Food and Drug Administration. There were about two more cases per every 1,000 patients given the drugs instead of a placebo, the FDA staff said in a review dated May 23
Epilepsy drug may help alcoholics
sea-maid submitted, created time 6 months 2 days (www.nature.com)
A drug used to treat epilepsy could also ease cravings in alcoholics, say researchers who have investigated the effect in rats.
Epilepsy drug saves rats from seizures
jane2007 submitted, created time 8 months 3 weeks (www.nature.com)
Scientists have discovered that a drug already used to control a type of epileptic seizure can also prevent future seizures in rats. Although many medications are used to control the symptoms of epilepsy, this is the first time that a drug has successfully halted progression of the disease.
"Three-parent" technique: mitochondrial replacement could prevent muscular dystrophy and epilepsy
Darkfrog submitted, created time 9 months 3 weeks (news.nationalgeographic.com)
It sounds more impressive than it is -- they've replaced the mitochondria, not portions of the somatic DNA.
A team at Newcastle University has constructed ten embryos, presumably viable, that hold DNA from one man and two women. Doctors see this technique as a means by which parents carrying genetic diseases may have their own (mostly) genetic offspring without going all the way to sperm donors, egg donors or surrogates
In Epilepsy Genes, Two Wrongs Do Make a Right
yangjane submitted, created time 1 year 3 weeks (www.scientificblogging.com)
Inheriting two genetic mutations that can individually cause epilepsy might actually be “seizure-protective,” said Baylor College of Medicine researchers the journal Nature Neuroscience.
Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy
kitty submitted, created time 1 year 1 month (www.pnas.org)
Mutations in the GABAA receptor γ2 subunit are associated with childhood absence epilepsy and febrile seizures. To understand better the molecular basis of absence epilepsy in man, we developed a mouse model harboring a γ2 subunit point mutation (R43Q) found in a large Australian family. Mice heterozygous for the mutation demonstrated behavioral arrest associated with 6-to 7-Hz spike-and-wave discharges, which are blocked by ethosuximide, a first-line treatment for absence epilepsy in man.
Nicotine rush hinges on sugar in neurons
bianjie submitted, created time 1 year 4 months (www.eurekalert.org)
A study in Nature Neuroscience online proposes a role for sugar as the hinge that opens a gate in the cell membrane and brings news of nicotine arrival. Finding could lead to improved treatments for substance addiction, depression, epilepsy and other disorders.
Evidence found for novel brain cell communication
bianjie submitted, created time 1 year 4 months (www.eurekalert.org)
An article published today, July 16, 2007, in Proceedings of the National Academy of Sciences provides strong evidence for a novel type of communication between nerve cells in the brain. The findings may have relevance for the prevention and treatment of epilepsy, and possibly in the exploration of other aspects of brain functions, from creative thought processes to mental illnesses such as schizophrenia. The discovery suggests the first new model of brain function since the 1940s.
Human Herpes Virus 6B Is Associated With Mesial Temporal Lobe Epilepsy
broadcast submitted, created time 1 year 6 months (www.sciencedaily.com)
There is strong evidence that one particular type of epilepsy is associated with a viral infection, according to new research. The international group of researchers, led by Steve Jacobson from National Institute of Neurological Disorders and Stroke, USA, found DNA from the virus, Human Herpes Virus 6B (HHV-6B) in specific regions of the brains in 11 of 16 patients with mesial temporal lobe epilepsy (MTLE) referred for investigation compared with zero of seven (0%) patients without MTLE.
julie submitted, created time 1 year 6 months (www.biologynews.net)
"Increasing the amount of SUMO, a small protein in the brain, could be a way of treating diseases such as epilepsy and schizophrenia, reveal scientists at the University of Bristol, UK. Their findings are published online today in Nature."
Epileptic Seizures Affected By Estrogen
psychologist submitted, created time 1 year 6 months (www.sciencedaily.com)
In more than a third of women with epilepsy, seizures fluctuate across the menstrual cycle, due in part to continually fluctuating effects of estrogen on the neural circuitry in the hippocampus, a region of the brain involved in learning and memory - and in epileptic seizures.
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