Cell cycle status in neurodegeneration

sea-maid submitted, created time 5 months 5 days (genomebiology.com)

Profiling of gene expression changes in mice harbouring the neurodegenerative Wlds mutation shows a strong correlation between changes in cell cycle pathways and altered vulnerability of terminally differentiated neurons.

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Hold on for dear life

sea-maid submitted, created time 5 months 3 weeks (www.jcb.org)

Steve Frisch and Hunter Francis find that epithelial cells that lose touch with the extracellular matrix kill themselves by anoikis.

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A Nonapoptotic Cell Death Process, Entosis, that Occurs by Cell-in-Cell Invasion

dedu submitted, created time 11 months 3 weeks (www.cell.com)

“Epithelial cells require attachment to extracellular matrix (ECM) to suppress an apoptotic cell death program termed anoikis. Michael et al. describe a nonapoptotic cell death program in matrix-detached cells that is initiated by a previously unrecognized and unusual process involving the invasion of one cell into another, leading to a transient state in which a live cell is contained within a neighboring host cell. Live internalized cells are either degraded by lysosomal enzymes or released

5 comments | Blog It | Email It | Keywords: entosis tumor suppression cell death apoptosis cancer tumors matrix-detached cells ECM epithelial cells

Blood vessels grown from patient's own tissues used successfully in human patients

Darkfrog submitted, created time 1 year 1 month (www.nytimes.com)

Thirteen months and so far so good. Unlike earlier techniques used in Japan, which involved growing cells on a scaffold that slowly dissolved after implantation, scientists in Argentina grew whole stretches of blood vessel from the patients' own cells. The patients in question have damaged veins and arteries in their arms from regular dialysis.

This does not involve stem cells of any kind. A strip of skin is removed from the patient, but the fibroblast and endothelial cells are taken from the inside of the veins in that strip of skin

1 comment | Blog It | Email It | Keywords: rejection tissue rejection epithelial cells fibroblasts arteries veins cardiovascular surgery cardiovascular vascular vascular surgery stem cells stem cell in vitro tissue culture transplants dialysis

Role of p14ARF in TWIST-mediated senescence in prostate epithelial cells

jiangyun submitted, created time 1 year 3 months (carcin.oxfordjournals.org)

Recently, TWIST, a basic helix-loop-helix transcription factor, is suggested to be an oncogene because of its overexpression in many types of human cancer and its positive role in promoting cell survival. The aim of this study was to investigate the role of TWIST on the growth of human epithelial cells.

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Molecular characterization of centriole assembly in ciliated epithelial cells

Reviver submitted, created time 1 year 4 months (www.jcb.org)

"Ciliated epithelial cells have the unique ability to generate hundreds of centrioles during differentiation. We used centrosomal proteins as molecular markers in cultured mouse tracheal epithelial cells to understand this process. Most centrosomal proteins were up-regulated early in ciliogenesis, initially appearing in cytoplasmic foci and then incorporated into centrioles. Three candidate proteins were further characterized. The centrosomal component SAS-6 localized to basal bodies and the proximal region of the ciliary axoneme, and depletion of SAS-6 prevented centriole assembly

Submit comment | Blog It | Email It | Keywords: CD8 T cells differentiation Corneal epithelial cells epithelial cells

Benign pulmonary epithelial inclusions within the pleura

saury submitted, created time 1 year 4 months (www.diagnosticpathology.org)

"The normal visceral and parietal pleura are composed of a mesothelium-lined layer of fibrous connective tissue, consisting predominantly of collagen and elastin fibers, with interspersed nerves, lymphatics, and blood vessels. There is no normal epithelial component to the pleura, and the histologic finding of epithelial cells within pleural tissue typically indicates the presence of a malignant process. The one documented exception to this rule is the occasional occurrence of endometriotic implants, which can result in cyclic thoracic symptomatology and occasionally even hemothorax

Submit comment | Blog It | Email It | Keywords: epithelial cells Corneal epithelial cells vaginal epithelial T cells

Differential in vitro inhibitory activity against HIV-1 of alpha-(1-3)- and alpha-(1-6)-D-mannose specific plant lectins : Implication for microbicide development

annatto submitted, created time 1 year 5 months (www.translational-medicine.com)

"HHA faintly inhibited attachment to HEC-1A cells of the R5-tropic HIV-1Ba-L strain, in a dose-dependent manner, whereas GNA moderately inhibited HIV adsorption in the same context, but only at high drug doses. Only HHA, but not GNA, inhibited HIV-1JR-CSF transcytosis in a dose-dependent manner. By confocal microscopy, HHA, but not GNA, was adsorbed at the epithelial cell surface, suggesting that HHA interacts specifically with receptors mediating HIV-1 transcytosis. Both plant lectins partially inhibited HIV attachment to MDDC

Submit comment | Blog It | Email It | Keywords: HEC-1A cells T cell epithelial cells MDDC