Early Stage Bone Cells Produce Potential Estrogen Substitute,

kavin submitted, created time 4 months 2 weeks (www.medicalnewstoday.com)

Cells on their way to forming bone also produce an estrogen-like substance that mimics the naturally occurring female sex hormone estradiol, investigators at the Yale School of Medicine reported Monday in the online edition of the Proceedings of the National Academy of Sciences.

Researchers hope such a molecule might provide some of the benefits but, hopefully, not the health risk of traditional hormonal therapies for menopause and bone loss.

Researchers in the laboratories of Thomas L

Submit comment | Blog It | Email It | Keywords: estradiol bone loss osteoblasts menopause women Estrogen Estrogen Receptors women's health women menopause bone marrow stem cells bone-forming cells

Antisense Oligodeoxynucleotides for Estrogen Receptor-bold italic beta and alpha Attenuate Estradiol's Modulation of Affective and Sexual Behavior, Respectively

Luneetty submitted, created time 1 year 7 months (www.nature.com)

Estradiol (E2) modulates affective and socio-sexual behavior of female rodents. E2's functional effects may involve actions through alpha and beta isoforms of estrogen receptor (ERs). The importance of E2's actions at these isoforms for anxiety (open field, elevated plus maze), depression (forced swim test), and sexual behavior (lordosis) was investigated using an antisense oligonucleotide (AS-ODN) strategy.ERbeta and ERalpha may be required for E2's modulation of affective and sexual behavior, respectively.

Submit comment | Blog It | Email It | Keywords: estradiol anxiety depression lordosis hippocampus hypothalamus

Estradiol-Dependent Decrease in the Orexigenic Potency of Ghrelin in Female Rats

athena submitted, created time 1 year 7 months (diabetes.diabetesjournals.org)

"Ghrelin, the only known orexigenic gut hormone, is secreted mainly from the stomach, increases with fasting and before meal initiation in humans and rats, and increases food intake after central or peripheral administration

Submit comment | Blog It | Email It | Keywords: hormone estradiol plasma neuropeptide