Articles with the keyword: 
Fat-regenerating "stem cells" found in mice
sea-maid submitted, created time 1 month 2 weeks (esciencenews.com)
Researchers have identified stem cells with the capacity to build fat, according to a report in the October 17th issue of the journal Cell, a Cell Press publication. Although they have yet to show that the cells can renew themselves, they have convirmed that they can renew fat tissue when transplanted into other animals. 
Too Good to Be True? Fat That Keeps You Thin
sea-maid submitted, created time 2 months 1 week (www.sciam.com)
Scientists have stumbled on a chemical in the body that could one day prevent or reverse diseases linked to obesity.
Researchers at Harvard University's School of Public Health (H.S.P.H.) report in Cell that palmitoleate, a newly discovered hormone produced by fat cells, is also a fatty acid. (Most hormones are proteins
Eating fatty fish lowers risk of dementia
sea-maid submitted, created time 2 months 1 week (www.msnbc.msn.com)
Eating tuna and other fatty fish may help prevent memory loss in addition to reducing the risk of stroke, Finnish researchers said on Monday.
Boosting good fat to burn off the bad
sea-maid submitted, created time 3 months 5 days (www.nature.com)
To most dieters, no fat is good fat. But in work published this week in Nature, an insight into the origin of a special class of calorie-burning fat cells could lead to new ways of boosting metabolism and combating obesity, researchers say.
This article outlines research suggesting that brown fat cells, which convert energy into heat but remain otherwise mysterious, may not arise from the same tissue as our garden-variety white fat cells
Patient, Heal Thyself: Body's Own Immune Cells Whack Late-Stage Tumor
sea-maid submitted, created time 3 months 1 week (www.sciam.com)
In what could be a breakthrough in cancer therapy, researchers report in The New England Journal of Medicine today that they succeeded in bolstering a patient's immune system enough to wipe out late-stage malignant tumors on its own. The scientists say the successful experiment could pave the way for new treatments of advanced cancer that spare patients the side effects of chemotherapy, which kills healthy as well as malignant cells.....
Beneficial Effects of Subcutaneous Fat Transplantation on Metabolism
sea-maid submitted, created time 6 months 1 week (www.cellmetabolism.org)
Subcutaneous (SC) and visceral (VIS) obesity are associated with different risks of diabetes and the metabolic syndrome. And from this study, it suggests that SC fat is intrinsically different from VIS fat and produces substances that can act systemically to improve glucose metabolism.
Regulation of the brown and white fat gene programs
kavin submitted, created time 6 months 1 week (www.ncbi.nlm.nih.gov)
In this paper, the data show that the regulated docking of the CtBP proteins on PRDM16 controls the brown and white fat-selective gene programs.
A Sweet New Role for EGFR ...in Cancer!
jerry submitted, created time 6 months 3 weeks (www.cancercell.org)
The epidermal growth factor (EGFR) has served as an attractive bull's-eye for targeted cancer therapies.
Although the importance of EGFR as an oncogenic tyrosine kinase seems well established, this issue of Cancer Cell adds a new wrinkle to the role of EGFR in cancer. They find that this new function does not require EGFR kinase activity.
In this study, the authors demonstrate that EGFR facilitates glucose transport into cells by associating with and stabilizing a sodium/glucose cotransporter (SGLT1)
jerry submitted, created time 6 months 3 weeks (sciencenow.sciencemag.org)
When we are struggling to lose weight, it may seem like new fat keeps showing up again and again!
That impression is half-right. Contrary to the accepted wisdom that humans don't make new fat cells, although one's total number of fat cells may not drop below a certain level, that doesn't mean that we can't add more. Previous research has suggested that under situations where people are consuming a high number of calories, their fat cells may increase in both size and number.
davidd submitted, created time 10 months 3 days (genomebiology.com)
Investigations performed in mice and humans have acknowledged obesity as a low-grade inflammatory disease. Several molecular mechanisms have been convincingly involved in activating inflammatory processes and altering cell composition in white adipose tissue (WAT). Here, they analyzed the transcriptomic signature of the WAT in obese human subjects, in stable weight conditions and after weight loss following bariatric surgery.
MicroRNAs Keep Tumors in Place
Eric wu submitted, created time 10 months 3 weeks (sciencenow.sciencemag.org)
When a cancer spreads, or metastasizes, it often becomes incurable. Now scientists are eying a new factor that may prompt tumor cells to start roaming: a deficit of molecules known as microRNAs, which modulate gene expression. Building on earlier work linking microRNAs to cancer, researchers have found that a lack of certain microRNAs encourages tumors to spread. They also report that in mice, the microRNAs can be manipulated to slow metastasis.
I am very glad that this news has opened a path toward explaining the follow article 'Breast-Cancer Genes May Come With Lower Risk'
Loss of β-Catenin Impairs the Renewal of Normal and CML Stem Cells In Vivo
small melon submitted, created time 11 months 2 weeks (www.cancercell.org)
"A key characteristic of stem cells and cancer cells is their ability to self-renew. To test if Wnt signaling can regulate the self-renewal of both stem cells and cancer cells in the hematopoietic system, they developed mice that lack β-catenin in their hematopoietic cells. Here we show that β-catenin-deficient mice can form HSCs, but that these cells are deficient in long-term growth and maintenance
Stem cell innovators find a way to cut out cancer
michealw submitted, created time 1 year 19 hours (www.reuters.com)
Researchers who figured out how to make valued embryonic stem cells out of ordinary skin cells said on Friday they had found a way to cut one cancer-causing ingredient out of the mix.
The Body's Internal Clock Adversely Affected By High-Fat Diet
june submitted, created time 1 year 3 weeks (www.medicalnewstoday.com)
The researchers found that mice fed a fatty diet quickly develop changes in their normal activity patterns. The animals begin eating more during the day, when mice -- being nocturnal -- are supposed to be asleep. They also exhibit changes in the molecular components of the circadian clock and in important aspects of metabolic chemistry.
Tick, Tock: Fat Disrupts the Clock
wugongliang submitted, created time 1 year 3 weeks (sciencenow.sciencemag.org)
A burger, fries, and a double fudge sundae for dessert is probably not the best recipe for a good night's sleep. Indeed, a new study shows that in mice, high-fat diets seem to disrupt the body's natural day and night rhythms. The work may help scientists understand why obesity, diabetes, and sleep disruption are often intertwined in human patients.
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