FOXO and insulin signaling regulate sensitivity of the circadian clock to oxidative stress

bianjie submitted, created time 1 year 3 months (www.pnas.org)

Circadian rhythms can be regulated by many environmental and endogenous factors. We show here a sensitivity of circadian clock function to oxidative stress that is revealed in flies lacking the foxo gene product. When exposed to oxidative stress, wild-type flies showed attenuated clock gene cycling in peripheral tissues, whereas foxo mutants also lost behavioral rhythms driven by the central clock.

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