A structural–functional basis for dyslexia in the cortex of Chinese readers

Biochemical characterization of a recombinant Japanese encephalitis virus RNA-dependent RNA polymerase

angelfish submitted, created time 1 year 5 months (www.biomedcentral.com)

”As a first step toward the understanding of the molecular mechanisms for JEV RNA replication and ultimately for the in vitro reconstitution of viral RNA replicase complex, we for the first time established an in vitro JEV RdRp assay system with a functional full-length recombinant JEV NS5 protein and characterized the mechanisms of RNA synthesis from nonviral and viral RNA templates. The full-length recombinant JEV NS5 will be useful for the elucidation of the structure-function relationship of this enzyme and for the development of anti-JEV agents.“

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Information available at cut rates: structure and mechanism of ribonucleases

athena submitted, created time 1 year 8 months (www.sciencedirect.com)

"Ribonucleases are counterweights in the balance of gene expression and are also involved in the maturation of functional RNA. Recent structural data reveal how ribonucleases recognize and cleave targets, in most cases with the catalytic assistance of metal cofactors. Many of these enzymes are ‘processive’, in that they make multiple scissions following the binding of substrates; crystallographic data can account for this solution behaviour

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Comparative analysis of genome tiling array data reveals many novel primate-specific functional RNAs in human

Cassidy submitted, created time 1 year 10 months (www.biomedcentral.com)

Widespread transcription activities in the human genome were recently observed in high-resolution tiling array experiments, which revealed many novel transcripts that are outside of the boundaries of known protein or RNA genes. Termed as "TARs" (Transcriptionally Active Regions), these novel transcribed regions represent "dark matter" in the genome, and their origin and functionality need to be explained. Many of these transcripts are thought to code for novel proteins or non-protein-coding RNAs

Submit comment | Blog It | Email It | Keywords: functional RNA Transcriptionally Active Region